Research Status,Problems and Countermeasures of Lyotropic Liquid Crystal in New Drug Delivery Systems of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20190947
- VernacularTitle: 溶致液晶在中药新型给药系统中的研究现状、存在问题及其对策
- Author:
Tian-jian YE
1
;
Mei-juan MA
2
;
Shuai QIAN
2
;
Yuan GAO
2
;
Ming-jun YU
3
;
Yuan-feng WEI
2
Author Information
1. Zhejiang Yongning Pharmaceutical Co. Ltd., Taizhou 318020, China
2. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
3. Dongshan Community Health Service Center, Nanjing 211101, China
- Publication Type:Research Article
- Keywords:
lyotropic liquid crystal;
traditional Chinese medicine;
new drug delivery system;
application prospect;
liquid crystal nanoparticles;
industrialization;
quality evaluation system
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(16):229-234
- CountryChina
- Language:Chinese
-
Abstract:
Lyotropic liquid crystal is an ordered system with various geometric shapes or three-dimensional structures formed by the interaction of amphiphilic molecules dissolved in polar solvents, and has the characteristics of excellent drug applicability, high drug loading, good bioadhesive property and high transdermal permeability. Through a comprehensive analysis of the research results in this research group and the related research reports of LLC drug delivery system, the authors systematically discussed the research value, development potential and research status of LLC in the field of new drug delivery system of traditional Chinese medicine(TCM), especially in the percutaneous and mucosal drug delivery system and the oral microparticle drug delivery system of TCM. At the same time, due to the current research field of TCM-LLC drug delivery system starts late, many of the basic research problems to be further perfect, this paper had carried on the induction summary to these problems, and put forward the research countermeasures:①the basic research of TCM-LLC drug delivery system should be strengthened by referencing the research experience and methods of LLC drug delivery system of single chemical component combined with TCM characteristics, ②the research on the release mechanism of the chemical components in TCM should be strengthened, and the basic research on the LLC drug delivery system of synchronized sustained release TCM should be carried out, ③development of new LLC materials applicable to TCM, ④the quality evaluation system of TCM-LLC should be improved, ⑤to explore the LLC preparation process suitable for industrialization.
