Effect of Traditional Chinese Medicine on Hepatic Disease by Inhibiting TLR4 Signaling Pathway
10.13422/j.cnki.syfjx.20191405
- VernacularTitle: 基于TLR4信号通路的中药抗肝脏疾病作用研究进展
- Author:
Ru-nan NONG
1
;
Jing-jing WANG
1
;
Yan-chun WU
2
;
Shu-ling LIU
2
;
Si-xiang LIU
1
;
Zhi-pin ZHOU
1
Author Information
1. Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China
2. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530001, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine;
Toll-like receptor 4 (TLR4);
anti-liver disease;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(16):201-212
- CountryChina
- Language:Chinese
-
Abstract:
Liver disease is the general term for all diseases that occur in the liver. In recent years, traditional Chinese medicine has certain advantages in the treatment of liver diseases. With a high experimental study value, good clinical efficacy and less adverse reactions, it has broad prospects. Toll-like receptor 4 (TLR4) signaling pathway is closely related to liver diseases. Its mechanism is to activate nuclear factor-κB (NF-κB) through tlr4-mediated signaling pathway, inhibit the secretion of such inflammatory factors as interleukin-1(IL-1), interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-α), and the inflammatory damage of liver cells, so as to further inhibit the effect of IL-1,IL-6, TNF-α in activating Hepatic Stellate Cell(HSC). The ways of blocking TRL4 pathway are as follows:Inhibiting the expression of TLR4,Inhibiting the dimerization of TLR4. Blocking intracellular signal transduction:①acting on the binding protein; ②acting on the kinase IRAKs; ③acting on TLRAFst. In these ways, the TRL4 pathway is blocked, the inflammation is inhibited, and the anti-liver disease effect is achieved. Therefore, inhibiting or enhancing TLR4 signaling pathway or intervening in some links of TLR4 signaling pathway has become a new strategy for the treatment of liver diseases. Toll-like receptor 4 signaling pathway has become one of the targets of traditional Chinese medicine (TCM) against liver diseases. In this paper, the recent literatures on the effect of TCM in resisting activation of TLR4 signaling pathway and the effect of anti-liver diseases through monomers and effective parts of TCM, extracts of TCM and compound prescriptions of TCM were collected and summarized to provide important guiding significance and direction for the treatment of liver diseases by TCM and WM in the next step.
