Clinical Efficacy of Modified Xiao Wuweizitang Combined with Massage Manipulation on Chronic Post-infection Cough
10.13422/j.cnki.syfjx.20191234
- VernacularTitle: 小五味子汤加减配合推拿手法治疗小儿慢性感染后咳嗽的临床观察
- Author:
Lan-xuan WANG
1
;
Hai-ling LUO
2
;
He-qiu RUAN
1
Author Information
1. Hainan Provincial People's Hospital, Haikou 570311, China
2. Hainan Children's Hospital, Haikou 570311, China
- Publication Type:Research Article
- Keywords:
post-infection cough;
children;
syndrome of wind-pathogenic pulmonary embedding;
Xiao Wuweizitang;
massage manipulation;
immunity;
inflammatory reaction
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(16):85-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of modified Xiao Wuweizitang combined with massage manipulation on chronic post-infection cough (syndrome of wind-pathogenic pulmonary embedding), and immunity and inflammatory factors. Method: One hundred and thirty-five patients were randomly divided into control group and observation group by random number table. Patients (59 cases) in control group got Suhuang Zhike capsules, 1 granule/time for 3 to 6-year-old children, 2 granules/time, 3 times/days for 6 to 12-year-old children, and massage manipulation, 1 time/day. Patients (63 cases) in observation group got modified Xiao Wuweizitang combined with massage manipulation. A course of treatment was 10 days. Before treatment, and at the 5th and 10th day after treatment, visual analogue score of cough (VAS), cough symptom, syndrome of wind-pathogenic pulmonary embedding and leicester cough questionnaire (LCQ) were scored. And levels of CD3+, CD4+, CD8+, CD4+/CD8+, interleukin-8, IL-4, tumor necrosis factor-α (TNF-α), substance P (SP) and calcitonin gene related peptide (CGRP) were detected. Result: At the 5th and 10th day after treatment, scores of VAS, cough symptom and syndrome of wind-pathogenic pulmonary embedding in observation group were lower than those in control group (P<0.01), and the clinical efficacy was superior to that in control group (χ2=7.513,P<0.01). The disappearance rate of cough in observation group was 57.81%, which was higher than 38.98%in control group (χ2=4.356, P<0.05). And the average time of disappearance of cough was shorter than that in control group (P<0.01). Scores of LCQ questionnaire (physiology, psychology and society) and the total score were higher than those in control group (P<0.01), and levels of TNF-α, IL-8, IL-4, CGRP and SP were lower than those in control group (P<0.01). Conclusion: Modified Xiao Wuweizitang combined with massage manipulation can relieve cough symptom, shorten the cough course, increase rate of the disappearance of cough, improve the quality of life of children, regulate immune function of children, reduce airway inflammation, airway hyperresponsiveness and cough reflex sensitivity.
