Correlation Between Telomere and Cardiovascular Aging and Traditional Chinese Medicine Intervention
10.13422/j.cnki.syfjx.20191725
- VernacularTitle: 端粒与心血管衰老及补肾活血中药干预的相关性
- Author:
Xi-jie LI
1
;
Lian DUAN
2
;
Jie WANG
2
Author Information
1. The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650021, China
2. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
- Publication Type:Research Article
- Keywords:
telomere;
telomerase;
cardiovascular disease;
aging;
tonifying kidney
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(17):187-193
- CountryChina
- Language:Chinese
-
Abstract:
With the advance of aging in the world, aging and its relevant cardiovascular diseases have become an important concern for medical care. Aging is a universal and multifactorial process characterized by a gradual decline in physiological functions, cell dysfunction and a variety of diseases. Telomere shortening is currently a hallmark of vascular aging. The shortening of telomere length is accelerated by exposure to smoking, obesity and other factors. Telomere shortening and dysfunction play crucial roles in the pathogenesis of senile-related cardiovascular diseases. Cardiovascular risk factors, such as smoking, high blood pressure, diabetes, obesity and stress are considered to increase oxidative stress or inflammation, accelerate the shortening of telomeres, and protect the healthy telomere length. Previous studies have also shown that telomere shortening is closely related to atherosclerotic cardiovascular disease. This may be an effective biomarker for the risk stratification of cardiovascular disease. According to the theory of traditional Chinese medicine(TCM), human aging and kidney deficiency are accompanied. The heart and kidney are interrelated and mutually constrained for coordinating water and fire. Impaired heart function due to kidney deficiency and self-aging can cause relevant cardiovascular diseases. The study found that TCM or prescriptions for activating blood circulation to remove blood stasis and many kidney-reinforcing TCM or prescriptions are likely to affect cardiovascular diseases by altering telomere length and telomerase activity. In today' s aging society, TCM for promoting blood circulation, removing blood stasis and tonifying kidney from the perspective of telomere is of great significance for the pathological mechanism of cardiovascular diseases.
