Research on Treatment of Chronic Cough Based on Cluster Analysis and Factor Analysis
10.13422/j.cnki.syfjx.20191746
- VernacularTitle: 基于聚类分析和因子分析的慢性咳嗽用药规律探索
- Author:
Qin-jun YANG
1
;
Ming-xiang HAN
2
;
Ze-geng LI
2
;
Xin-heng WANG
1
;
Ya-ting GAO
1
;
Jia-bing TONG
2
;
Cheng YANG
2
;
Chuan-bo WANG
3
Author Information
1. Anhui University of Chinese Medicine, Hefei 230038, China
2. Institute of Respiratory Disease Prevention and Treatment of Traditional Chinese Medicine, Anhui Academy of Chinese Medicine, Hefei 230031, China
3. The Second Hospital of Anhui Medical University, Hefei 230601, China
- Publication Type:Research Article
- Keywords:
chronic cough;
frequency analysis;
system cluster analysis;
factor analysis;
medication law;
experience of famous doctors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(19):155-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize medication law of prescription and clinical experience on the treatment of chronic cough through data mining technology. Method:The formula information of 650 cases of chronic cough cases diagnosed and treated by professor HAN Ming-xiang was processed with data mining technology, and system cluster analysis and factor analysis were conducted by SPSS Statistics 22.0. Result:High-frequency medicines of professor HAN Ming-xiang for treating chronic cough were Stemonae Radix, Citri Reticulatae Pericarpium, Asteris Radix et Rhizoma and other 37 herbs, their frequency of occurrence accounted for 80.52%. According to the efficacy, the medicines could be classified into 10 categories, such as expectorant cough antiasthmatic drugs, tonifying deficiency drugs, and diaphoretic drugs. Cluster analysis showed 5 combinations of drugs. Factor analysis yielded 13 common factors, such as Stemonae Radix-Asteris Radix et Rhizoma-Farfarae Flos-Cynanchi Stauntonii Rhizoma et Radix, Asari Radix et Rhizoma-Schisandrae Chinensis Fructus-Zingiberis Rhizoma-Fritillariae Thunbergii Bulbus. Conclusion:Combined with clinical experience, it can be concluded that clinical treatment of professor HAN Ming-xiang for chronic cough attaches great importance to the pathogenesis of wind-evil, Yang deficiency and cold phlegm underlying lung, phlegm and blood stasis and Qi stagnation. The treatment mainly starts from the lung and spleen, with the method of warm and moist, or with some traditional Chinese medicines with the function of removing phlegm by warming the lung, dispersing cold by thinning the surface, strengthening the spleen and resolving phlegm, strengthening the lung and fixing the surface, and relieving spasmolysis by wind.
