Comparison of Dryness Effect Between Atractylodes lancea and A. chinensis
10.13422/j.cnki.syfjx.20191246
- VernacularTitle: 南苍术与北苍术的燥性效应比较
- Author:
Yi-yi XU
1
;
Ling-hang QU
1
;
Guo-sheng CAO
1
;
Ying XIE
1
;
Lin LEI
1
;
Kun-yu XIAO
1
;
Yan-ju LIU
1
Author Information
1. Technical Engineering Research Center of Traditional Chinese Medicine Processing in Hubei Province, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
- Publication Type:Research Article
- Keywords:
Atractylodes lancea;
A. chinensis;
volatile oil;
dryness;
aquaporin 2;
submandibular gland;
hemorheology
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(19):87-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dryness effect of Atractylodes lancea and A. chinensis. Method:Sixty normal and healthy SD rats were randomly divided into 6 groups(10 in each group), including normal saline group, soybean oil group, low-dose(46.25 mg·kg-1·d-1) group and high-dose(500 mg·kg-1·d-1) group of A. lancea, low-dose(46.25 mg·kg-1·d-1) group and high-dose(500 mg·kg-1·d-1) group of A. chinensis, the dosing volume was 0.01 mL·g-1, and the drug was administered orally for 21 days. Taking average daily water intake, submandibular gland tissue, urine volume and expression of aquaporin 2(AQP2) in the kidney, and whole blood viscosity as the evaluation indexes, the dryness effect of long-term administration of equal doses of volatile oil from A. lancea and volatile oil from A. chinensis on rats was observed. Result:Compared with the soybean oil group, long-term administration of high doses of volatile oil from A. lancea and volatile oil from A. chinensis could significantly increase average daily water intake, urine volume and whole blood viscosity; decrease the expression of AQP2, and atrophy the acini of submandibular gland, but there was no significant difference between the two groups. Effects of volatile oil from A. lancea and A. chinensis with low dose on dryness of rats were not significant. Conclusion:There is no significant difference between the dryness effect of volatile oil from A. lancea and A. chinensis in the same dose. It is proved that the rationality of A. lancea and A. chinensis are universal in clinical practice, and this study provides experimental basis for rational use of Atractylodis Rhizoma.
