Intervention of Modified Yupingfeng San Combined with Aspirin on D-dimer， PagT Levels of RSA with Seronegative APS
10.13422/j.cnki.syfjx.20191126
- VernacularTitle: 玉屏风散加味联合阿司匹林干预RSA合并血清阴性APS及对D-二聚体，PagT的影响
- Author:
Shi-min WU
1
;
Yong TAN
2
Author Information
1. Nanjing University of Chinese Medicine, Nanjing 210029, China
2. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
- Publication Type:Research Article
- Keywords:
modified Yupingfeng San;
seronegative antiphospholipid syndrome(SN-APS);
recurrent spontaneous abortion(RSA);
fetal protection
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(19):10-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of aspirin combined with modified Yupingfeng San on patients with recurrent spontaneous abortion and Seronegative antiphospholipid syndrome. Method:From December 2016 to March 2018, 109 cases of recurrent spontaneous abortion patients with seronegative antiphospholipid syndrome in Affiliated Hospital of Nanjing University of Chinese Medicine were selected as the study objects. According to the random number table, they were divided into three groups:blank group, control group and study group. The blank group was treated with folic acid tablets, 1 pill/time, qd, as placebo, the control group was treated with folic acid tablets, 1 pill/time, qd, Danshen pills, 4 pills/time, tid, and aspirin, 1 pill/time, tid, and the study group was treated with folic acid tablets, 1 pill/time, qd, aspirin, 1 pill/time, tid, and modified Yupingfeng San, 150 mL/time, bid. These patients were all asked for pregnancy preparation for 1 year and treated with aspirin, 1 pill/time, tid, and progesterone pills, 1 pill/time, tid, since the beginning of pregnancy until 13 weeks or abortion. The pregnancy rate, miscarriage rate, coagulation index before and after treatment, traditional Chinese medicine (TCM) symptom score as well as months of abortion were all observed and compared. Result:The coagulation index and TCM symptom score of the study group were significantly lower than those before treatment (P<0.05), and the coagulation index of the control group was lower than before treatment. In terms of the coagulation index, the study group was significantly lower than the blank group (P<0.05). In terms of TCM symptom scores, the study group got lower scores than other two groups (P<0.05). Besides, in terms of the total abortion rate and the abortive rate beyond the months of abortion, the study group was significantly lower than the blank group (P<0.05), and the total abortion rate of the blank group was significantly higher than that of control group (P<0.05). Conclusion:The data proved that the combination of anti-coagulation medicine with either single herb or herbal compound can improve the curative effect of the patients, and traditional Chinese herbal compound can regulate the immune system, reduce the thrombosis and improve the symptoms of TCM, which made the curative efficacy more prominent. However, more samples were needed for further research. Because the time of fetal protection may not change the outcome of pregnancy, the therapy should be maintained at least until the end of the early pregnancy.
