Overview of Experimental Methods for Antimicrobial Activity of Natural Drugs
10.13422/j.cnki.syfjx.20191051
- VernacularTitle: 天然药物抑菌活性实验方法的研究概述
- Author:
Qi RAN
1
;
Zhuo-zhuo ZHAO
1
;
Xiu-kun LIU
1
;
Peng-xin YU
1
;
Li-peng LIANG
2
;
Na-na LI
1
;
Xin-bo SONG
3
;
Wei LI
1
Author Information
1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2. Beida Cistanche(Tianjin) Biotechnology Co. Ltd., Tianjin 300000, China
3. Tianjin Zhongyi Pharmaceutical Co. Ltd., Tianjin 301617, China
- Publication Type:Research Article
- Keywords:
drug resistance;
natural medicines;
traditional Chinese medicine;
drug sensitivity;
bacteriostasis test;
in vitro and in vivo;
antibiotics
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(20):214-221
- CountryChina
- Language:Chinese
-
Abstract:
The antibiotics have obvious antibacterial and anti-inflammatory effects, but their toxic side effect, secondary infection and bacterial resistance have become a global problem. Traditional Chinese medicine(TCM) has always been the treasure of traditional culture and national characteristics in China since ancient times. It also has remarkable effect on inhibiting the growth of bacteria and killing pathogenic bacteria. The research on bacteriostatic experiment of TCM has gradually become a hot topic. Sensitivity experiments for such natural medicines have gradually become a research hotspot, but the complexity and particularity of natural medicines will vary with different methods. Therefore, different methods of drug sensitivity experiments should be matched with different natural drugs. By collecting and sorting out the relevant literature at home and abroad, this paper systematically summarizes the commonly used in vitro, in vivo and their combination bacteriostasis experimental methods of natural medicine activity, analyses the advantages and disadvantages of each method in the process of application, finds that different kinds of natural drugs have different applicable methods, and puts forward suggestions for the operation of each experimental method, in order to provide ideas for the selection of antibacterial susceptibility research experiments of natural medicines. It also provides a reliable reference method for solving the problem of antibiotic abuse and the development and utilization of natural medicines.
