Side Effect and Attenuation of Triptolide
10.13422/j.cnki.syfjx.20191429
- VernacularTitle: 雷公藤甲素毒性作用及减毒研究的整合探析
- Author:
Bin LIU
1
;
Dan-ping FAN
1
;
Hai-yang SHU
2
;
Xiao-juan HE
1
;
Cheng LYU
1
;
Ai-ping LYU
3
Author Information
1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China
3. School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
- Publication Type:Research Article
- Keywords:
triptolide;
side effect;
attenuation study
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(20):181-190
- CountryChina
- Language:Chinese
-
Abstract:
Triptolide (TP) is a kind of epoxy diterpene lactone compound extracted from xylem of Tripterygium wilfordii (TWHF). It is one of the main active components of TWHF, with anti-inflammatory, immunomodulatory and anti-tumor activities and pharmacological effect. It can be used in the treatment of rheumatoid arthritis and such cancers as leukemia, breast cancer, pancreatic cancer and lung cancer. In recent years, TP has been gradually applied in clinic and basic research, with a certain curative effect. But it also has certain side effect on digestive system, urinary system, reproductive system, circulatory system and immune system, including liver dysfunction, reduced fertility, chest tightness, heart palpitations, bradycardia, atrioventricular block, arrhythmia, kidney dysfunction, lymphoid organ atrophy, lymphoid tissue necrosis of lymphocytes, and reduction in the number of cells, impaired immune function. These toxic and side effect have greatly restricted the clinical application of TP. In the meantime, the researches and development related to preparations of TP have also been restricted, which has aroused wide attention from clinicians and researchers. To improve the therapeutic effect of TP and reduce the toxicity of TP in the process of application, domestic and foreign researchers have made a lot of studies and attempts, such as changing the chemical structure of TP to improve its solubility, developing drug delivery system to reduce its toxicity and using combination therapy with traditional Chinese herbal medicines to increase efficiency and reduce toxicity. In this paper, the toxic dose and mechanism of TP, TP's derivatives, drug loading system, compatibility and attenuation were integrated to provide ideas for further researches on toxicity and attenuation of TP.
