Network Pharmacology Research of Wuzi Yanzongwan in Treatment of Male Infertility
10.13422/j.cnki.syfjx.20191940
- VernacularTitle: 五子衍宗丸治疗男性不育症的网络药理学探讨
- Author:
Jin DING
1
;
Yao-sheng ZHANG
2
;
Jian-wei SHANG
2
Author Information
1. Shenzhen Baoan Hospital of Traditional Chinese Medicine(Group) Affiliated to Guangzhou University of Chinese Medicine, Shenzhen 518133, China
2. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Publication Type:Research Article
- Keywords:
network pharmacology;
male infertility;
Wuzi Yanzongwan;
phosphatidylinositol-3-kinases (PI3K)/protein kinase B (Akt) pathway;
oxidative stress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(20):25-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Exploring the material basis and mechanism of Wuzi Yanzongwan in the treatment of male infertility based on network pharmacology. Method:Traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) was used to screen the active ingredients and targets in Wuzi Yanzongwan. GeneCards, OMIM and PharmGkb databases were used to screen the targets of male infertility. R language software was used to screen common targets of drugs and diseases, Pharmaceutical active ingredients-disease target interaction network was constructed by using Cytoscape software. The common target protein interaction network (PPI) was constructed by STRING platform, the gene ontology(GO) analysis of common target was analyzed by ClueGo plug-in, and Kyoto encyclopedia of genes and genomes(KEGG) pathway was enriched by R language software. Result:A total of 72 active ingredients were obtained from Wuzi Yanzongwan, and 35 possible targets for the treatment of male infertility were obtained. These targets are mainly involved in biological processes such as oxidation and antioxidant activity, and are mainly concentrated in phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt) and hypoxia inducible factor-1(HIF-1) signaling pathways. Conclusion:The network pharmacology confirmed the multi-component, multi-target and multi-pathway action characteristics of Wuzi Yanzongwan, predicted the possible mechanism of Wuzi Yanzongwan in the treatment of male infertility, and provided theoretical basis for further study of its active ingredients and mechanism.
