Analysis on Pathogenesis of Diabetes Mellitus Based on Theory of Ascending and Descending of Qi Movement of Gut Microbiota
10.13422/j.cnki.syfjx.20191422
- VernacularTitle: 基于肠道菌群从气机升降理论探析糖尿病发病机制
- Author:
Jian-wei ZHU
1
;
Yu-lin LENG
1
;
Xiu-juan ZHOU
1
;
Kai-shan WEI
1
;
Xiao-xu FU
1
;
Chun-guang XIE
2
Author Information
1. Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 610072, China
2. Teaching Hospital of Chengdu University of TCM, Chengdu 610072, China
- Publication Type:Research Article
- Keywords:
ascending and descending of Qi movement;
gut microbiota;
diabetes mellitus;
homeostasis of internal environment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(21):189-195
- CountryChina
- Language:Chinese
-
Abstract:
The gut microbiota and its metabolites play a critical role on health maintenance, because they are involved in the absorption and metabolism of nutrients in the human bodies. This is also similar to traditional Chinese medicine (TCM) view that the ascending and descending of Qi movement affects Yin-Yang, Qi-blood, pneuma and body fluid, viscera and meridians of our bodies. More and more studies have demonstrated that gut microbiota is closely related to the development and progression of diabetes and its complications. Gut microbiota disorder could affect host metabolic signaling pathways, thereby promoting the formation and development of diabetes. The smooth ascending and descending of Qi movement is the basic form of maintaining host metabolic homeostasis, whose dysfunction however can lead to internal environment disturbance. Based on the theory of ascending and descending of Qi movement, this paper focuses on the pathogenesis of imbalanced intestinal flora in the process of the induction of diabetes mellitus from a dynamic perspective. It is assumed that the imbalance of Qi ascending and descending may act as a trigger for such symptoms as lung Qi impairment, spleen deficiency to dissipating essence, liver Qi stagnation and kidney Yang deficiency. Under this circumstance, gut microbiota will be out of balance, which will further lead to the nutrient substance metabolic disturbance in the body, and thus induce diabetes. Thus, it is significant to explore the regulatory mechanism of gut microbiota and its metabolites on diabetes based on the theory of ascending and descending of Qi movement, so as to reveal the scientific connotation of TCM in regulating substance metabolism homeostasis in the body.
