Efficacy and Mechanism of Danlu Tongdu Tablets on Lumbar Disc Herniation with Kidney Deficiency and Stasis Syndrome
10.13422/j.cnki.syfjx.20191634
- VernacularTitle: 丹鹿通督片治疗腰椎间盘突出症肾虚瘀阻证的疗效与机制
- Author:
Bin-hong YAN
1
;
Qian NIU
2
;
Zhi-jian FU
3
;
Fan YANG
2
;
Dao-rui YU
4
;
Kun NIU
2
Author Information
1. First Affiliated Hospital of Hainan Medical College, Haikou 570102, China
2. College of Traditional Chinese Medicine, Hainan Medical University, Haikou 571101, China
3. Oriental Red Ginseng Academy of Ethnic Medicine, Haikou 572600, China
4. College of Basic Medicine and Life Sciences, Hainan Medical College, Haikou 571101, China
- Publication Type:Research Article
- Keywords:
lumbar disc herniation;
kidney deficiency and stasis syndrome;
Danlu Tongdu tablets;
relapse rate;
nucleus pulposus reabsorption;
immuno-inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(22):66-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe short-term and long-term efficacies of Danlu Tongdu tablets on lumbar disc herniation (LDH) with kidney deficiency and stasis syndrome, and its effect on nucleus pulposus reabsorption and immunoinflammatory factors. Method: One hundred and sixty patients were randomly divided into control group (80 cases) and observation group by random number table. Patients in control group (80 cases) got acupoint massage and acupuncture, 1 time/day. In addition to the therapy of control group, patients in observation group were also given Danlu Tongdu tablets, 4 tablets/time, 3 times/days. A course of treatment was 12 weeks, and a 9-month follow-up was recorded. Lumbago and leg pain were recorded by visual simulation (VAS) before treatment and at the first, second, third month after treatment. Before and after treatment, Japanese orthopaedic association (JOA), symptoms and signs were scored. During the 9-month follow-up, relapse rate and relapse time were recorded, and VAS and JOA were scored. Absorption of nucleus pulposus was assessed, and levels of interleukin-1 (IL-1), IL-17, tumor necrosis factor-α (TNF-α), matrix metalloproteinases-3 (MMP-3) were detected. Result: By rank sum test, the clinical efficacy in observation group was better than that in control group (Z=2.125, P<0.05), and scores of JOA was better than that in control group (Z=1.924, P<0.05). At the first, second and third months after treatment, VAS scores of low back pain, leg pain were lower than those in control group (P<0.01), while the decline range were more than that in control group (P<0.01). And scores of symptoms and signs were lower than that in control group (P<0.01), whereas scores by dimensions of JOA scale and the total score of JOA were all higher than those in control group (P<0.01). Complete absorptivity of nucleus pulposus in observation group was 61.11%, which was higher than 42.03%in observation group (χ2=5.138, P<0.05). Levels of IL-1, IL-17, TNF-α and MMP-3 were lower than that in control group (P<0.01). Relapse rate in observation group was 23.61%, which was lower than 40.58%in control group (χ2=4.668, P<0.05). Average recurrence time was longer than that in control group (P<0.05), score of VAS was lower than that in control group (P<0.05), and the total score of JOA was higher than that in control group (P<0.05). Conclusion: In addition to acupuncture and massage therapy, Danlu Tongdu tablets can also be used to relieve pain and ameliorate function, improve clinical efficacy, reduce relapse rate, promote nucleus pulposus reabsorption, and relieve inflammation of nerve root.
