Clinical Efficacy of Modified Zhenwutang Combined with Zhengji Technique on Cold-dampness Arthralgia Syndrome Caused by Knee Osteoarthritis at Episode
10.13422/j.cnki.syfjx.20192032
- VernacularTitle: 真武汤加味联合整脊手法治疗膝骨关节炎发作期寒湿痹阻证的临床观察
- Author:
Ping LI
1
;
Qing SHI
1
;
He LI
1
;
Liu-xin QU
1
;
Song GAO
1
;
Guang-juan KE
1
Author Information
1. Zhongda Hospital Affiliated of Southeast University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
knee osteoarthritis;
attack period;
cold-dampness arthralgia syndrome;
modified Zhenwutang;
chiropractic manipulation;
inflammatory factor;
quality of life
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(23):98-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the clinical efficacy of modified Zhenwutang combined with Zhengji technique on cold-dampness arthralgia syndrome caused by knee osteoarthritis (KOA) at episode and the effect on inflammatory factors of joint fluid. Method: One hundred and forty-eight patients were randomly divided into control group and observation group by random number table. Patients in control group got celecoxib capsules, 0.2 g/time, 1 time/day, and Zhengji technique with lumbar positioning oblique pulling and finger pressing for 12 times, 1 time for every two days, 3 times/week. Patients in observation group got modified Zhenwutang, 1 dose/day, and the same Zhengji technique. The course of treatment was 4 weeks. Before and after treatment, western Ontario and McMaster University Osteoarthritis index (WOMAC), pain and swelling, index of severity of osteoarthritis (ISOA), local signs of knee joint and cold-dampness obstruction syndrome were scored, and the score of quality of life were discussed by arthritis impact measurement scale 2 (AIMS2-SF). And levels of interleukin-1 beta (IL-1β), IL-17, tumor necrosis factor-alpha (TNF-α), substance P (SP) and calcitonin gene-related peptide (CGRP) were detected. Result: The clinical efficacy in observation group was better than that in control group (Z=2.131, P<0.05). Scores of pain from WOMAC scale, stiff, joint function and the total score of WOMAC were lower than those in control group (P<0.01), and scores of pain (walking pain, resting pain, tenderness), degree of swelling, ISOA, cold-dampness arthralgia syndrome and local signs of knee joint were lower than those in control group (P<0.01). And physical, symptoms, impact, social and work factor scores, the total scores of AIMS2-SF scale, IL-1β, IL-17, TNF-α, SP and CGRP were higher than those in control group (P<0.01). Conclusion: Modified Zhenwutang combined with Zhengji technique can relieve clinical symptoms of patients with cold-dampness arthralgia syndrome caused by knee osteoarthritis (KOA) at episode, ameliorate joint function to improve patients' quality of life, reduce the expression of proinflammatory factors and neuropeptides in synovial fluid, so as to inhibit the inflammatory response and controlling clinical symptoms.
