Clinical Efficacy of Modified Bingtitang in Treatment of Type 2 Diabetes Mellitus and Effect on Pancreas Islet Function
10.13422/j.cnki.syfjx.20192421
- VernacularTitle: 并提汤加减治疗2型糖尿病临床疗效及对胰岛功能的影响
- Author:
Tian-ci SUN
1
;
Wen LI
1
;
Fen LIU
1
;
Xin-qiao KE
1
;
Li YANG
1
Author Information
1. Shenzhen Longhua District Central Hospital, Shenzhen 518110, China
- Publication Type:Research Article
- Keywords:
type 2 diabetes mellitus;
traditional Chinese medicine treatment;
Bingtitang;
pancreas islet function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(24):60-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of modified Bingtitang in treatment of type 2 diabetes mellitus(T2DM) and its effect on pancreas islet function. Method:A total of 108 patients with T2DM were divided into two groups according to the digital number table method, with 54 cases in each group. The control group were given routine therapy of diabetic diet, proper exercise and blood sugar control, while the treatment group were orally given traditional Chinese medicine (TCM) and modified Bingtitang in addition to the therapy of the control group. The blood sugar, pancreas islet function-related indexes, TCM syndrome score, serum retinol binding protein 4 (RBP4) and Betatrohin levels were compared between two groups before and after treatment. The total effective rate was also compared. Result:After treatment, the fasting blood glucose (FPG), glycated hemoglobin (HbA1c), blood glucose variation coefficient (CV-FPG), insulin resistance index (HOMA-IR) of the treatment group were lower than those of control group (P<0.01), while the ratio of insulin secretion index (HOMA-IS), 30-minute insulin increment (I30) and blood glucose proliferation (G30) to(ΔI30/ΔG30)of treatment group were higher than those of the control group (P<0.01). The TCM score and the serum RBP4 level were lower than those of control group (P<0.01), while Betatrohin level was higher than that of the control group (P<0.01), and the total effective rate was higher than that of control group (P<0.05). Conclusion:In addition to the routine treatment, modified Bingtitang can effectively control blood sugar, improve pancreas islet function, and alleviate TCM syndromes, with a significant effect on T2DM. Its mechanism may be related to the regulation of serum RBP4 and Betatrohin levels.
