Prevalence of Pulmonary Arterial Hypertension in Korean Adult Patients with Systemic Sclerosis: Result of a Pilot Echocardiographic Screening Study.
10.4250/jcu.2016.24.4.312
- Author:
Su Jin YOO
1
;
Jae Hyeong PARK
;
Yunseon PARK
;
Jae Hwan LEE
;
Byung Joo SUN
;
Jinhyun KIM
;
In Seol YOO
;
Seung Cheol SHIM
;
Seong Wook KANG
Author Information
1. Division of Rheumatology, Department of Internal Medicine, School of Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, Korea. kangsw@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
Systemic sclerosis;
Pulmonary arterial hypertension;
Echocardiography;
Right heart catheterization;
Screening
- MeSH:
Adult*;
Arterial Pressure;
Cardiac Catheterization;
Cardiac Catheters;
Chungcheongnam-do;
Diagnosis;
Echocardiography*;
Humans;
Hypertension*;
Mass Screening*;
Mortality;
Prevalence*;
Prognosis;
Scleroderma, Systemic*;
Tricuspid Valve Insufficiency;
Vasodilator Agents
- From:Journal of Cardiovascular Ultrasound
2016;24(4):312-316
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality among patients with systemic sclerosis (SSc). Early detection and prompt treatment of PAH associated with SSc (SSc-PAH) result in better prognosis. We conducted echocardiographic study to presume the prevalence of PAH in Korean adult SSc patients and to diagnose SSc-PAH in their early stages with right heart catheterization (RHC). METHODS: We performed free of charge echocardiographic study including 37 adult SSc patients at the Chungnam National University Hospital. The possibility of PAH is determined by the estimation of pulmonary arterial pressure by peak tricuspid regurgitation velocity of > 3.0 m/s. Patients with possible PAH were recommended to undergo RHC to confirm the diagnosis. RESULTS: In 37 patients, 8 patients were suspected with PAH. Among them, 6 patients agreed to be examined with RHC, and 4 were confirmed with PAH. The prevalence of possible PAH was 21.6% (8 of 37 patients), and that of confirmed PAH was 10.8% (4 of 37 patients). Four patients who were confirmed with SSc-PAH through RHC have been treated with specific pulmonary vasodilators and maintained stable. CONCLUSION: Eight patients (21.6%) were possible PAH and 4 (10.8%) were diagnosed as SSc-PAH by RHC after the echocardiographic screening study of 37 adult SSc patients.
