Effect of Jiawei Changfengyin with Retention Enema Therapy on Th1/Th2 in Patients with Acute Radiation Proctitis
10.13422/j.cnki.syfjx.20190131
- VernacularTitle: 加味肠风饮保留灌肠对急性放射性直肠炎患者Th1/Th2的调节作用
- Author:
Meng LI
1
;
Ji SONG
1
;
Wen-bo ZHANG
1
;
Fei BO
1
;
Yu-jie CHEN
1
Author Information
1. Chengde Central Hospital, Chengde 067000, China
- Publication Type:Research Article
- Keywords:
acute radiation proctitis;
Changfengyin;
Xileisan;
pearl powder,retention enema;
Th1/Th2 cytokines
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(1):119-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the efficacy of Jiawei Changfengyin with retention enema therapy for acute radiation proctitis and investigate its influence on regulating levels of helper T cell(Th)1/Th2. Method: One hundred and twenty-eight patients were randomly divided into control group and observation group by random number table. Patients in control group (64 cases) got montmorillonite powder (3.0 g), dexamethasone (10 mg) and normal saline (100 mL), with retention enema therapy. Patients in observation group (64 cases) got Jiawei Changfengyin(Changfengyin+Xileisan+pearl powder), with retention enema therapy. Both groups of patients received enema once every night, and the treatment course was 4 weeks in both groups. Before and after treatment, scores of main symptoms, proctoscopy, routine examination of stool+occult blood, and KPS scores of quality of life were graded. Levels of Th1 cell factors[interleukin(IL)-1β, IL-8 and interferon-γ(IFN-γ)], Th2 cell factors (IL-4 and IL-10) were detected. Result: The total effective rate for comprehensive clinical efficacy was 95.31% in observation group, higher than 82.81% in control group (χ2=5.132, P<0.05). Scores of each symptom and the total scores in observation group were lower than those in control group (P<0.01). Degree of rectal mucosa injury in observation group was lighter than that in control group (Z=2.764, P<0.05). Score of rectal mucosal injury was lower than that in control group (P<0.01), but score of KSP was higher than that in control group(P<0.05). Levels of IL-1β, IL-8 and IFN-γ in observation group were lower than those in control group, while levels of IL-4 and IL-10 were higher than those in control group (P<0.01). Conclusion: Jiawei Changfengyin can relieve symptoms of acute radiation proctitis, promote healing of rectal mucosa, improve quality of life, and regulate Th1/Th2 cytokines, with good repairing effect for intestinal mucosa.
