Optimizing CAR structure to improve safety and efficiency of CAR-T cell therapy
10.3872/j.issn.1007-385x.2018.12.001
- VernacularTitle:优化CAR结构增强CAR-T细胞治疗的安全性和有效性
- Author:
DONG Jie
1
;
WANG Zhengxu
1
Author Information
1. (Biological Therapy Center, the Seventh Medical Center of PLA General Hospital [Former Army General Hospital of PLA]
- Publication Type:Journal Article
- Keywords:
tumor;
chimeric antigen receptor T（CAR-T）cell;
cell therapy;
immunotherapy;
molecular structure
- From:
Chinese Journal of Cancer Biotherapy
2018;25(12):1209-1217
- CountryChina
- Language:Chinese
-
Abstract:
CAR-T cell therapy has developed rapidly in recent years, and has achieved amazing results in the treatment of some malignant tumors of the blood system, but little progress has been made in the treatment of solid tumors. At present, the main problems to be solved in CAR-T cell therapy are: (1) enhancing the killing activity of CAR-T cells; (2) relieving the immunosuppressive state of tumors; (3) bringing CAR-T cells into solid tumors; (4) enhancing the safety of CAR-T cell therapy. By optimizing the structure of CAR, a series of defects in the CAR-T cell therapy can be overcome, and the curative effect of CAR-T can be enhanced and the complications can be alleviated. In this paper, some optimization and improvement measures and methods on the structure design of CAR in recent years are elaborated, and the effectiveness and safety of the CAR-T cell therapy are explored.
- Full text:20181201.pdf
