Progress of JAK-STAT pathway in the angiogenesis of glioma
10.3760/cma.j.issn.1006-9801.2019.11.019
- VernacularTitle: JAK-STAT通路在胶质瘤血管生成中的研究进展
- Author:
Xin YANG
1
;
Hubin DUAN
Author Information
1. Department of Neurosurgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Review
- Keywords:
Glioma;
Vascular endothelial growth factors;
JAK-STAT;
Angiogenesis
- From:
Cancer Research and Clinic
2019;31(11):789-792
- CountryChina
- Language:Chinese
-
Abstract:
Vascular nutrition transmission is an irreplaceable factor in the process of tumor formation. Blocking or reducing the energy transmission pathway of tumor can effectively resist the development of tumor. There is a close relationship between JAK-STAT signaling pathway and angiogenesis, especially research on the relationship between this pathway and vascular endothelial growth factor (VEGF) signal has produced many results in recent years. This review summarizes the induction of angiogenesis, drug development, and the discovery of antiangiogenic targets in the JAK pathway, providing some ideas for the treatment of glioma.
