The role of Erastin in ferroptosis
10.3760/cma.j.issn.1006-9801.2019.11.017
- VernacularTitle: Erastin在铁死亡中的作用
- Author:
Yuechen ZHAO
1
;
Lili ZHONG
2
;
Yinlong ZHAO
3
Author Information
1. Department of Radiotherapy, the Second Hospital of Jilin University, Changchun 130041, China
2. Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Research Center of the Second Hospital of Jilin University, Changchun 130041, China
3. Department of Nuclear Medicine, the Second Hospital of Jilin University, Changchun 130041, China
- Publication Type:Review
- Keywords:
Cell death;
Antineoplastic combined chemotherapy protocols;
Erastin;
Ferroptosis
- From:
Cancer Research and Clinic
2019;31(11):782-786
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a newly discovered form of cell death in recent years. Its essence is the cell peroxidation death caused by the accumulation of intracellular lipid reactive oxygen species (L-ROS) in a iron-dependent manner. As a highly efficient ferroptosis inducer, Erastin mediates ferroptosis through multiple molecules, such as cystine-glutamate transport receptor, voltage-dependent anion channel and p53. More importantly, Erastin can enhance the sensitivity of cancer cells to chemotherapy and radiotherapy, so it can be used as a new type of anticancer drug. This article reviews the discovery of Erastin, the pathways of ferroptosis, the pathways of Erastin-induced ferroptosis, the anti-tumor characteristics of Erastin, and the latest domestic and international research results.
