Progress of biological characteristics of stress granules and their relationship with tumors
10.3760/cma.j.issn.1006-9801.2019.11.016
- VernacularTitle: 应激颗粒的生物学特征及其与肿瘤关系的研究进展
- Author:
Xianying LI
1
;
Dalong YIN
;
Lianxin LIU
;
Jiabei WANG
Author Information
1. Department of Hepatic Surgery, the First Hospital Affiliated of Harbin Medical University, Harbin 150001, China
- Publication Type:Review
- Keywords:
Neoplasms;
Stress granules;
Antineoplastic drugs
- From:
Cancer Research and Clinic
2019;31(11):778-782
- CountryChina
- Language:Chinese
-
Abstract:
Eukaryotes inhibit the translation of mRNA under stress conditions and form particles-stress granules (stress granules). At present, stress granules have been proved to be related to the occurrence and development of a variety of diseases, including tumors. The production of stress granules is promoted by microenvironment such as hypoxia and hyperactive oxygen in tumor cells, while stress granules-related proteins such as G3BP1, RACK1, YB-1 and mammalian target of rapamycin (mTOR) can promote the occurrence and metastasis of tumors, but the mechanism is not yet clear. In addition, studies have linked the formation of stress granules to the survival of tumor cells during chemotherapy, and believe that stress granules play a role in the treatment of tumors by different anti-tumor drugs. This review introduces the biological characteristics of stress granules and their relationship with tumors.
