Correlation of the human papillomavirus infection status and genotyping with the result of liquid-based thin-layer cytology of cervix in the female physical examiners in Xi'an
10.3760/cma.j.issn.1006-9801.2019.11.001
- VernacularTitle: 西安地区女性体检者子宫颈人乳头瘤病毒感染情况及基因分型与液基薄层细胞学检查结果的关系
- Author:
Hongyun CHANG
1
;
Xiaofeng LI
;
Yuanyuan WANG
;
Pengfei NAN
;
Xiaoni ZHAO
;
Guanjun ZHANG
Author Information
1. Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
- Publication Type:Journal Article
- Keywords:
Human papillomavirus;
Genotype;
Cervical intraepithelial neoplasia;
Liquid-based cytology;
Xi'
an
- From:
Cancer Research and Clinic
2019;31(11):721-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of human papillomavirus (HPV) infection status and genotyping characteristics with the result of liquid-based thin-layer cytology (TCT) of the cervix in the female physical examiners in Xi'an.
Methods:The data of 5 163 female physical examiners who underwent HPV and TCT screening simultaneously in the First Affiliated Hospital of Xi'an Jiaotong University From June 2017 to June 2018 were collected to analyze HPV infection, genotyping and their relationship with TCT.
Results:Among the 5 163 examiners, 527 (10.21%) were HPV-positive, and the infection rate in the examiners over 60 years old was the highest [12.26% (57/465)]. Among HPV-positive examiners, the infection rate of single genotype was higher than that of multiple genotypes infection [75.90% (400/527) vs. 24.10% (127/527), P < 0.01]. The top four genotypes were type 52, 58, 53 and 16 accounting for 17.21% (121/703), 12.09% (85/703), 11.52% (81/703) and 10.67% (75/703), respectively, of the total frequency of HPV infection. Of the 5 163 examiners, 68 (1.32%) examiners were positive for TCT screening. There was no significant difference in the positive rate of TCT between HPV multiple genotypes-infected examiners and single genotype-infected examiners [11.02% (14/127) vs. 9.00% (36/400), χ2 = 0.460, P > 0.05]. Among 50 examiners with positive results of HPV and TCT tests, the top four genotypes were type 58, 52, 53 and 16, and they were in consistence with the overall HPV infection genotyping.
Conclusions:The HPV infection in the female physical examiners in Xi'an is dominated by the single genotype infection, and the main genotypes of HPV infection are type 52, 58, 53 and 16. The combined detection of HPV genotyping and TCT can improve the effectiveness of cervical lesions screening.
