Role of neurovascular dysfunction in vascular cognitive impairment and Alzheimer's disease
10.3760/cma.j.issn.1673-4165.2019.11.011
- VernacularTitle: 神经血管功能障碍在血管性认知损害和阿尔茨海默病中的作用
- Author:
Yifan JI
1
;
Xiaosha LI
1
;
Xiangyu LI
1
;
Peiyuan LYU
1
,
2
Author Information
1. Graduate School of Hebei Medical University, Shijiazhuang 050017, China
2. Department of Neurology, Hebei General Hospital, Shijiazhuang 050051, China
- Publication Type:Review
- Keywords:
Cognition disorders;
Cerebrovascular disorders;
Alzheimer disease;
Neurovascular coupling;
Blood-brain barrier
- From:
International Journal of Cerebrovascular Diseases
2019;27(11):860-864
- CountryChina
- Language:Chinese
-
Abstract:
The neurovascular unit consists of neurons, glial cells and cerebral blood vessels. Each eomponent synergistically regulates vasomotion and maintains the blood-brain barrier function to maintain the microenvironment homeostasis and ensure normal brain function. Cognitive impairment, especially in the advanced stage of dementia, places heavy economic and mental burdens on society and families. From the perspective of holistic view, this article expounds the role of neurovascular dysfuntion in the two major causes of cognitive impairment, including Alzheimer's disease and vascular cognitive impairment, and aims to provide possible clues for early prevention and treatment of these diseases.
