Impact of obstructive sleep apnea hypopnea syndrome on platelet function in patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.11.004
- VernacularTitle: 阻塞性睡眠呼吸暂停低通气综合征对缺血性卒中患者血小板功能的影响
- Author:
Mengfan LI
1
;
Tong WANG
;
Tengqun SHEN
;
Xinmei XU
;
Hairong SUN
;
Zhenguang LI
;
Jinbiao ZHANG
Author Information
1. Department of Neurology, WeiHai Municipal Hospital, Weihai 264200, China
- Publication Type:Clinical Trail
- Keywords:
Stroke;
Brain ischemia;
Sleep apnea, obstructive;
Platelet activation;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2019;27(11):819-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of obstructive sleep apnea hypopnea syndrome (OSAHS) on platelet function in patients with ischemic stroke.
Methods:Patients with ischemic stroke treated in the Department of Neurology, Weihai Municipal Hospital from January 2017 to November 2017 were collected prospectively. The presence or absence of OSAHS was determined by polysomnography. After oral administration of aspirin enteric coated tablets for 7±1 d, the maximum aggregation ratio (MAR) induced by arachidonic acid (AA) was determined by PL-12 Platelet Function Analyzer. MAR-AA ≥50% was defined as platelet hyperresponsiveness. Multivariate logistic regression analysis was used to evaluate the risk factors for platelet hyperresponsiveness in patients with ischemic stroke, and multiple linear regression analysis was used to determine the correlation between sleep parameters reflecting the severity of sleep apnea and MAR-AA.
Results:Among the 124 patients with ischemic stroke, 58 (46.77%) complicated with OSAHS, 66 (53.23%) without complicated with OSAHS; 84 (67.74%) had platelet hyperresponsiveness, and 40 (32.26%) had not platelet hyperresponsiveness. MAR-AA in the complicated OSAHS group was significantly higher than that in the non-complicated OSAHS group (48.98%±20.61% vs. 26.45%±15.15%; t=-6.858, P<0.001). Multivariate logistic regression analysis showed that OSAHS was an independent risk factor for platelet hyperresponsiveness in patients with ischemic stroke (odds ratio 9.551, 95% confidence interval 3.051-29.905; P<0.001). Multiple linear regression analysis showed that there was a significant linear relationship between apnea hypopnea index and MAR-AA (β=0.499, P<0.001).
Conclusions:OSAHS is an independent risk factor for platelet hyperresponsiveness in patients with ischemic stroke. Apnea hypopnea index is significantly correlated with MAR-AA.
