Research and application of PD-1/PD-L1 inhibitors in small cell lung cancer
10.3760/cma.j.issn.1673-422X.2019.11.011
- VernacularTitle: PD-1/PD-L1抑制剂在小细胞肺癌中的研究及应用
- Author:
Wenjuan WU
1
;
Guixiang LI
;
Mingli DU
;
Lei ZHAO
Author Information
1. Department of Gamma Knife Therapy, Second Hospital of Lanzhou University, Lanzhou 730030, China
- Publication Type:Review
- Keywords:
Small cell lung carcinoma;
Immunotherapy;
PD-1/PD-L1
- From:
Journal of International Oncology
2019;46(11):695-698
- CountryChina
- Language:Chinese
-
Abstract:
Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a very high degree of malignancy. Currently, the standard treatment for SCLC is still chemoradiotherapy, and although SCLC is sensitive to chemotherapy in the early stage, recurrence and metastasis often occur due to drug resis-tance. In recent years, immunotherapy has made some progress in the study of SCLC. The immunodetection point programmed death-1 (PD-1) and its ligand (PD-L1) inhibitors, such as nivolumab, atezolizumab and pabolizumab, have shown good antitumor activity in clinical studies of SCLC, and PD-1/PD-L1 inhibitors combined with chemotherapy have shown better efficacy, providing a new strategy for the treatment of SCLC.
