Mechanism of RhoA in malignant tumors
10.3760/cma.j.issn.1673-422X.2019.11.009
- VernacularTitle: RhoA在肿瘤中的作用机制
- Author:
Guangshun SUN
1
;
Jie MEI
2
;
Meng ZHOU
3
;
Di WU
3
;
Jiadong PAN
2
;
Xiao LIU
1
Author Information
1. Department of Thyroid and Breast Surgery, Wuxi People′s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China
2. Department of Oncology, Wuxi People′s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China
3. First Clinical College, Nanjing Medical University, Nanjing 211166, China
- Publication Type:Review
- Keywords:
Neoplasms;
Neoplasm metastasis;
Cytoskeleton;
RhoA
- From:
Journal of International Oncology
2019;46(11):686-691
- CountryChina
- Language:Chinese
-
Abstract:
As a representative member of the Rho family, RhoA plays an important role in the oncogenesis and development of malignant tumors. According to previous studies, RhoA functions as a key regulator in mediating actin polymerization, cytoskeletal structure remodeling, cell polarity changes, epithelial-mesenchymal transition and so on. RhoA can promote multiple malignant phenotypes of tumor cells, such as migration, invasion, etc. At present, mainstream research believes that RhoA functions as oncogene in the carcinogenesis of tumors. Downregulated RhoA can inhibit tumor growth and progression, which can be used as a potential target for clinical anti-tumor therapy.
