Analysis of bio-markers in osteoarthritis early diagnosis
10.3760/cma.j.issn.1673-4203.2019.11.013
- VernacularTitle: 生物标记物在骨关节炎早期诊断中的应用分析
- Author:
Junjie ZENG
1
;
Lifeng MA
;
Jiaming ZHAO
;
Ai GUO
Author Information
1. Department of Orthopedic, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
- Publication Type:Review
- Keywords:
Biological markers;
Osteoarthritis;
Early diagnosis
- From:
International Journal of Surgery
2019;46(11):776-779
- CountryChina
- Language:Chinese
-
Abstract:
Through analysis and summary of the biological characteristics of various biomarkers, to explore the reliability of different markers for early diagnosis of osteoarthritis. Cartilage oligomeric matrix protein, N-terminal crosslinked telopeptide of type Ⅰ collagen and C-terminal crosslinked telopeptide of type Ⅱ collagen are the possible effective markers in osteoarthritis early diagnosis. Hyaluronic acid and C-terminal crosslinked telopeptide of type I collagen are more suitable for evaluating the ollurrence and derelopment of osteoarthritis. The efficacy of miRNA and lncRNA in osteoarthritis diagnosis and evaluation remains to be proved. Each marker may has two or more biological effect, this paper will focus on finding out an accurate and stable marker with the analysis and summary of present bio-markers.
