Research progress on DNA methylation in deep vein thrombosis
10.3760/cma.j.issn.1673-4203.2019.11.012
- VernacularTitle: 深静脉血栓性疾病的DNA甲基化研究进展
- Author:
Jing LU
1
;
Xiaohu GE
Author Information
1. Department of Vascular Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
- Publication Type:Review
- Keywords:
Venous thrombosis;
Gene;
DNA methylation;
MicroRNAs
- From:
International Journal of Surgery
2019;46(11):772-775
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of deep vein thrombosis has increased year by year in the world, and it has become one of the serious diseases that threaten human life. In severe cases, it can lead to fatal pulmonary embolism. The pathogenesis of deep vein thrombosis is the result of the interaction of multiple genetic environmental factors. Therefore, regulation of gene expression by modification of DNA and histones may help to further reveal the pathogenesis of deep vein thrombosis, and reactivation or silencing of some genes that are inhibited or overexpressed by aberrant methylation may be a major therapeutic target for deep vein thrombosis. The author reviews the current status of DNA methylation studies related to deep vein thrombosis.
