Effect of Xiaoyaosan on sexual behavior and inflammatory factors of rat with depression
10.3760/cma.j.issn.1673-4246.2019.11.013
- VernacularTitle: 逍遥散对慢性轻度不可预见应激抑郁大鼠性行为及炎性细胞因子的影响
- Author:
Yueyun LIU
1
;
Jingjing GAO
2
;
Xin ZHAO
1
;
Lifeng YUE
3
;
Gang WANG
4
;
Hairong YU
5
;
Na WEI
5
;
Xin MA
5
;
Yuan LIANG
6
Author Information
1. Academy of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2. Master Degree Candidate in 2017, Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
3. The Third Department of Brain Deseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
4. Department of Peripheral Vascular Surgery, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
5. Department of B-mode Ultrasound, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
6. Department of Magzine, Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
- Publication Type:Journal Article
- Keywords:
Xiao Yao San;
Chronic mild unpredictable stress;
Depression;
Interleukin-6;
Interleukin-1beta;
Dopamine;
Rats
- From:
International Journal of Traditional Chinese Medicine
2019;41(11):1208-1212
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of Xiaoyaosan on sexual behavior and inflammatory factors of rat with depression.
Methods:The establishing depressive rat models of chronic mild unpredictable stress were established. The rats were randomly divided into model group and Xiaoyaosan group, 15 in each group. The Xiaoyaosan group was given 4.612 5 g/(kg•d) Xiaoyaosan, the blank group and the model group were intragastrically administered with normal saline once daily. After 4 weeks of oral administration, mount frequency and perineal licking numbers to female rats in each experimental group were observed by sexual behavior experiment, and the spleen index and thymus index were calculated. The serum DA, IL-1β, IL-6 levels were tested by Elisa.
Results:Compared with the normal group, the mount frequency (4.42 ± 3.91 vs. 11.58 ± 6.54), perineal licking numbers (3.53 ± 3.29 vs. 16.36 ± 10.68) and serum DA levels (14.14 ± 0.71 pg/ml vs. 17.44 ± 4.06 pg/ml) in the model group significantly decreased (P<0.05 or P<0.01), and the thymus index (0.012 4 ± 0.001 8 vs. 0.009 3 ± 0.001 7), serum IL-1β (39.45 ± 11.98 pg/ml vs. 28.62 ± 6.61 pg/ml), IL-6 levels (9.74 ± 1.49 pg/ml vs. 6.40 ± 0.66 pg/ml) significantly increased (P<0.05 or P<0.01). Compared with the model group, the contents of serum DA in Xiaoyaosan group (15.90 ± 1.24 pg/ml vs. 14.14 ± 0.71 pg/ml) increased significantly (P<0.01), and the thymus index (0.009 9 ± 0.001 3 vs. 0.012 4 ± 0.001 8) and IL-6 levels (8.32 ± 0.39 pg/ml vs. 9.74 ± 1.49 pg/ml) decreased significantly (P<0.05).
Conclusions:The Xiaoyaosan had a therapeutic effect on immune dysfunction and increases the expression of serum dopamine in depressive rats, which may be one of the mechanisms of its anti-depression.
