Effect of Yinlian gargle combined with sodium bicarbonate for the adults with oral fungal infections of acute myeloid leukemia chemotherapy induced myelosuppression
10.3760/cma.j.issn.1673-4246.2019.11.010
- VernacularTitle: 银连含漱液联合碳酸氢钠治疗急性髓系白血病化疗后骨髓抑制期口腔真菌感染临床研究
- Author:
Chenxi XIAO
1
;
Zhaowu ZHOU
Author Information
1. The First Affiliated Hospital of Guangdong University of Traditional Chinese Medicine, Guangzhou 510405, China
- Publication Type:Clinical Trail
- Keywords:
Leukemia, myeloid, acute;
Mouth;
Fungi;
Yinlian gargle;
Antifungal drugs (TCD);
Sodium bicarbonate
- From:
International Journal of Traditional Chinese Medicine
2019;41(11):1197-1200
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of Yinlian gargle combined with Sodium bicarbonate on treatment of adult with oral fungal infections of acute myeloid leukemia chemotherapy Induced myelosuppression.
Methods:Totally 120 patients with acute myeloid leukemia for chemotherapy Induced myelosuppression complicated with oral fungal infections were randomly divided into the western medicine group, the traditional Chinese medicine (TCM) group, the integrated TCM and western medicine group and the control group, with 30 patients in each group. The integrated TCM and western medicine group was treated by Yinlian gargle and sodium bicarbonate solution alternately, the TCM group was treated by Yinlian gargle, the western medicine group was treated by Yinlian gargle and sodium bicarbonate solution, and the control group was treated by basic treatment and normal saline 4 times a day for 5 days. Before and after treatment, the Oral pH, white spot area, the safety were observed. And to calculate the total efficiency of each group.
Results:The oral pH (6.98 ± 0.13 vs. 6.57 ± 0.14, 6.61 ± 0.11, 6.23 ± 0.09, F=273.930 )in the integrated TCM and western medicine group were significantly higher than those among other groups (P<0.05). The white spot area (2.21 ± 1.93 mm2 vs. 6.32 ± 2.35 mm2, 5.99 ± 2.64 mm2, 7.83 ± 2.56 mm2, F=29.842) in the integrated TCM and western medicine group were significantly lower than those among other groups (P<0.05). The effective rate in TCM and western medicine group was 96.7% (29/30), TCM group 60.0% (18/30), western medicine group 63.3% (19/30), and the control group 31.0% (9/29), which showed significantly difference among four groups (χ2=27.425, P<0.01).
Conclusions:The Yinlian gargle combined with sodium bicarbonate on treatment of adult acute myeloid leukemia chemotherapy induced myelosuppression with oral fungal infections was effective.
