Clinical research of Lishi-Jianpi-Quyu decoction combined with conventional western medicine for the patients with oral lichen planus
10.3760/cma.j.issn.1673-4246.2019.11.009
- VernacularTitle: 利湿健脾祛瘀汤结合西医常规疗法治疗口腔扁平苔藓临床研究
- Author:
Baohui GUO
1
;
Jingwen WANG
;
Hui SONG
Author Information
1. Department of Dental, Beijing Xuanwu Hospital of Traditional Chinese Medicine, Beijing 100050, China
- Publication Type:Clinical Trail
- Keywords:
Lichen Planus, Oral;
Lishi-Jianpi-Quyu decoction;
Tumor necrosis factor-alpha;
Interleukin;
Immune reconstitution
- From:
International Journal of Traditional Chinese Medicine
2019;41(11):1193-1196
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the therapeutic effect of Lishi-Jianpi-Quyu decoction combined with conventional western medicine for the oral lichen planus (OLP).
Methods:A total of 80 OLP patients who met the inclusion criteria were divided into two groups by random number table method, 40 in each group. The control group was treated with conventional medicine, while the research group were treated with Lishi-Jianpi-Quyu decoction on the basis of control group. Two groups were treated for 4 weeks. The severity of oral mucosal lesions was assessed by REU scale, and oral discomfort was assessed by VAS scale. The serum tumor necrosis factor-α (TNF-α), IL-6 and IL-8 levels were detected by ELISA, peripheral blood CD3+, CD4+ levels were detected by flow cytometry, and the ratio of CD4+/CD8+ was calculatedand the clinical efficacy was evaluated.
Results:The effective rate of research group was 82.5% (33/40), while the control group was 62.50% (25/40), and the difference between two groups was statistically significant (χ2=9.031, P=0.003). After treatment, TNF-α (1.19 ± 0.28 μg/L vs. 3.59 ± 0.72 μg/L, t=19.807), IL-6 (11.14 ± 2.04 ng/L vs. 16.34 ± 3.20 ng/L, t=8.666), IL-8 (1.15 ± 0.61 ng/L vs. 2.04 ± 0.76 ng/L, t=5.776) of research group were significantly lower than the control group (P<0.01). The serum CD3+ (64.02% ± 5.16% vs. 58.07% ± 4.85%, t=5.314), CD4+ (41.26% ± 3.61% vs. 37.15% ± 3.04%, t=5.508), CD4+/CD8+ (1.60 ± 0.43 vs. 1.31 ± 0.40, t=3.668) of research group were significantly higher than those of the control group (P<0.01). After treatment, the REU score and VAS score in the research group were significantly lower than that in the control group (t=10.980, 11.146, P<0.01).
Conclusions:The Lishi-Jianpi-Quyu decoction combined with conventional western medicine can improve the clinical symptoms of OLP, reduce the level of serum inflammatory cytokines, and enhance the body's immunity and improve the curative effect.
