The efficacy of modified Quyuan decoction in treating children upper airway cough symptom complex with syndrome of phlegm and heat accumulated in lung
10.3760/cma.j.issn.1673-4246.2019.11.006
- VernacularTitle: 加味取渊汤结合西医常规疗法治疗小儿上气道咳嗽综合征痰热郁肺证临床研究
- Author:
Yinghui LI
1
;
Jin ZHANG
1
;
Huanwei YANG
2
;
Lichun ZHU
1
;
Chengxiang LIU
1
Author Information
1. Paediatrics of Department, Qinhuangdao Traditional Chinese Medicine Hospital, Qinhuangdao 066000, China
2. Respiratory of Department, Qinhuangdao Traditional Chinese Medicine Hospital, Qinhuangdao 066000, China
- Publication Type:Clinical Trail
- Keywords:
Cough;
Child;
Upper airway cough syndrome;
Syndrome of phlegm and heat accumulated in lung;
Quyuan decoction;
Interleukin
- From:
International Journal of Traditional Chinese Medicine
2019;41(11):1179-1183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of modified Quyuan decoction in the treatment of Children upper airway cough symptom complex with syndrome of phlegm and heat accumulated in lung.
Methods:Eighty-two Children with upper airway cough symptom complex who met the inclusion criteria were randomly divided into 2 groups with 41 in each group. In the control group, monteluster sodium chewing tablets were taken orally and budesonide suspension was inhaled. The observation group took modified Quyuan decoction on the basis of the control group. Both groups were treated continuously for 2 weeks and followed up for 6 months. The levels of interleukin (IL)-8 and IL-13 were detected by double-antibody-sandwich ELISA, and the symptoms and signs were scored before and after treatment, as well as the symptoms of phlegm, heat and stagnation of lung, cough and pharynx. The efficacy was evaluated and recurrence rate was recorded.
Results:The total effective rate 95.12% (39/41) in the observation group was obviously higher than 75.61% (31/41) in the control group (χ2=4.783, P=0.029). After treatment, the serum level of IL-8 (51.61 ± 5.94 ng/L vs. 71.25 ± 7.99 ng/L, t=12.631) and IL-13 (27.62 ± 3.20 ng/L vs. 34.91 ± 4.01 ng/L, t=9.099) in the observation group were significantly lower than those in the control group (P<0.01). After treatment, the scores of cough, nasal obstruction, runny nose, nasal itching, expectoration, sneezing, secretion of posterior pharyngeal wall and pharyngeal mucosa in the observation group were all significantly lower than those in the control group (t values were 7.762, 6.831, 6.217, 6.944, 6.408, 6.212, 7.268, 7.109, all Ps<0.01). The scores of cough, expectoration, blood in sputum, chest pain, dry mouth and fever were significantly lower than those of the control group (t values were 9.439, 6.831, 6.982, 10.115, 12.031 and 10.443, all Ps<0.01). Scores of daytime and nighttime cough symptoms were significantly lower than those of the control group (t values were 7.012, 7.241, respectively, all Ps<0.01). The scores of pharyngeal pain, pharyngeal dryness and pharyngeal foreign body sensation were significantly lower than those of the control group (t values were 6.003, 6.106, 6.318, respectively, all Ps<0.01). In the 6 months' follow-up observation, the recurrence rate was 17.7% (3/17) in the observation group and 53.9% (7/13) in the control group, and the difference between the two groups was statistically significant (χ2=4.344, P=0.037).
Conclusions:The modified Quyuan decoction combined with conventional western medicine can improve the symptoms and signs of upper airway cough symptom complex of children with syndrome of phlegm and heat accumulated in lung.
