Effect of Heshi-Gejiugao on neuroendocrine immune network in women with perimenopausal syndrome
10.3760/cma.j.issn.1673-4246.2019.11.005
- VernacularTitle: 何氏葛九膏对围绝经期综合征患者神经内分泌免疫网络的影响
- Author:
Xinghai YAN
1
;
Bin WU
;
Jihong CAI
;
Xinxia JIA
;
Tao YANG
;
Zhuo HE
;
Ling HAN
;
Fudong HE
Author Information
1. Xinjiang Changji Hospital of Traditional Chinese Medicine, Changji 831100, China
- Publication Type:Clinical Trail
- Keywords:
Climacteric syndrome;
Perimenopause;
Heshi-Gejiugao;
Hypothalamus;
Pituitary gland;
Ovary;
Adrenal glands;
Receptors, neurotransmitter
- From:
International Journal of Traditional Chinese Medicine
2019;41(11):1174-1178
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the mechanism of Heshi-Gejiugao on the nerve endocrine immune network in the treatment of perimenopausal syndrome.
Methods:A total of 100 patients with perimenopausal syndrome were randomly divided into treatment group and control group, 50 cases in each group. The control group was only given general treatment, while the treatment group was treated with Heshi-Gejiugao on the basis of general treatment for 30 days. The clinical efficacy, Kupperman score, nerve, endocrine and immune related indexes of the two groups before and after treatment were observed.
Results:The total effective rate was 96.0% (48/50) in the treatment group and 50.0% (25/50) in the control group. There was significant difference between the two groups (χ2=37.639, P<0.01). The Kupperman score (17.52 ± 2.73 vs. 24.22 ± 6.87, t=6.409) in the treatment group was significantly lower than that in the control group (P<0.01). After treatment, NE (1 878.08 ± 931.57 ng/m vs. 1 278.43 ± 866.32 ng/ml, t=3.331), DA (1 568.56 ± 597.15 ng/ml vs. 1 183.62 ± 798.72 ng/ml, t=2.729) in the treatment group were significantly higher than those in the control group (P<0.05); E2 (42.12 ± 9.77 pg/ml vs. 35.91 ± 12.55 pg/ml, t=2.761), FSH (62.70 ± 15.96 mIU/ml vs. 72.67 ± 30.18 mIU/ml, t=2.065), LH (33.88 ± 12.18 mIU/ml vs. 42.93 ± 9.83 mIU/ml, t=4.089) were significantly lower than those of the control group (P<0.05). CD3+ (1 087.34/μl ± 432.19/μl vs. 918.27/μl ± 199.72/μl, t=2.511), CD4+ (738.16/μl ± 326.75/μl vs. 588.43/μl ± 212.55/μl, t=2.716) and CD4/CD8 (1.87 ± 0.56 vs. 1.16 ± 0.55), t=6.483) were significantly higher than those of the control group (P<0.05); CD8+ (788.32/μl ± 214.56/μl vs. 976.37/μl ± 318.62/μl, t=3.462) was significantly lower than that of the control group (P<0.05).
Conclusions:Heshi-Gejiugao can reduce the symptoms and improve the quality of life by regulating the multi target and multi direction of the neuroendocrine immune network of perimenopausal patients.
