Research on the clinical effect of Jiuwei-Zhenxin granules and buspirone hydrochloride tablets for geriatric anxiety patients
10.3760/cma.j.issn.1673-4246.2019.11.004
- VernacularTitle: 九味镇心颗粒联合盐酸丁螺环酮片治疗老年期焦虑症临床研究
- Author:
Minghua XIA
1
;
Xiaowei LIU
;
Hua ZHU
;
Xiangdong JI
Author Information
1. Department of Geriatric Psychiatry in Wuxi Mental Health Center, Wuxi 214151, China
- Publication Type:Clinical Trail
- Keywords:
Anxiety disorders;
Aged;
Jiuwei-Zhenxin granules;
Butyrocyclosterone hydrochloride tablets;
Receptors, neurotransmitter;
Heart rate
- From:
International Journal of Traditional Chinese Medicine
2019;41(11):1170-1173
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of Jiuwei-Zhenxin granules and buspirone hydrochloride tablets for geriatric anxiety patients.
Methods:A total of 136 elderly anxiety patients who met the inclusion criteria were randomly divided into two groups with 68 patients in each group. Patients in the control group were treated with butyrocyclone hydrochloride tablets, while the patients in the treatment group were treated with Jiuwei-Zhenxin granules on the basis of control group. Both groups were treated for 4 weeks. The average R-R interval standard deviation at 24 h (SDNN), the standard deviation of the mean normal R-R interval value for every 5 minutes in 24 h (SDANN) and mean square root of inter-period difference between adjacent R-R at 24h (RMSSD) were measured by heart rate variation analyzer. The 5-hydroxytryptamine (5-HT), norepinephrine (NE) and dopamine (DA) were detected using ELISA. The HAMA scale was used to evaluate anxiety and adverse reactions.
Results:After treatment, the SDNN (132.04 ± 30.17 ms vs. 107.23 ± 23.44 ms, t=16.901), RMSSD (70.12 ± 21.85 ms vs. 46.43 ± 20.09 ms, t=20.367) and SDANN (136.45 ± 27.18 ms vs. 125.62 ± 20.92 ms, t=6.945) of the treatment group were significantly higher than those of the control group (P<0.01). The serum 5-HT (119.69 ± 10.24 ng/L vs. 142.26 ± 13.71 ng/L, t=21.523), NE (126.47 ± 20.15 ng/L vs. 205.84 ± 23.12 ng/L, t=35.776), DA (130.12 ± 15.95 ng/ml vs. 156.47 ± 15.09 ng/ml, t=14.198) were significantly lower than those of the control group (P<0.01). The HAMA scores of the treatment group at week 1, 2, 3 and 4 after treatment were significantly lower than those of the control group (t=2.105, 4.116, 4.270, 3.369, P<0.05).
Conclusions:The Jiuwei-Zhenxin granules combined with buspironone hydrochloride tablets can reduce the anxiety of elderly anxiety patients, and its mechanism may be related to regulating the body's neurotransmitter to inhibit autonomic nervous dysfunction and reduce anxiety.
