Analysis of the utilization of antibacterial drugs in 100 cases of old community-acquired pneumonia with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6706.2019.11.008
- VernacularTitle: 慢性阻塞性肺疾病合并社区获得性肺炎100例抗菌药物使用情况分析
- Author:
Dongmei CHEN
1
;
Li ZHANG
2
;
Mingbiao LI
2
;
Jianping MAI
1
Author Information
1. Department of Pharmacy, Xiaolan People's Hospital, Zhongshan, Guangdong 528415, China
2. Department of Respiratory Diseases, Xiaolan People's Hospital, Zhongshan, Guangdong 528415, China
- Publication Type:Journal Article
- Keywords:
Pulmonary disease, chronic obstructive;
Pneumonia;
Antibacterial drugs;
Rational administration of drug
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(11):1311-1315
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the utilization of antibacterial drugs in the old community-acquired pneumonia (CAP) with chronic obstructive pulmonary disease(COPD) in our hospital.To analyze the rational application of antibacterial drugs, thus to provide a powerful reference for clinical diagnosis and treatment.
Methods:From June 2011 to June 2013, 100 patients with COPD and CAP were selected in Xiaolan People's Hospital.The average age was (76.95±6.57) years old, including 62 males and 38 females.The utilization of antibacterial drugs was investigated by retrospective study in the patients.
Results:In the course of treatment, the rate of using the antibacterial drugs in 100 patients was 100%, concerning 13 varieties of 5 major categories, including β-lactam (including β-lactam/β-lactamase inhibitors), quinolones, carbapenems, macrolides, aminoglycosides.The largest frequency was piperacillin/sulbactam, up to 92.Ceftezole, cefotian and azithromycin were less than 0.9 for DUI in DDDS ordering 10 drugs, it showed that the frequency was insufficient or the dosage was too small.For example, insufficient frequency of cephalosporin once a day and small dosage of azithromycin 0.25g once a day.Combination with two kinds of antimicrobial drugs was common, it was relatively rational between the combination of drugs, usually cephalosporins+ quinolones, β-lactam/β-lactamase inhibitors+ quinolones, β-lactam/β-lactamase inhibitors+ macrolides.
Conclusion:The etiology of 100 elderly patients with COPD and CAP in our hospital is mainly Gram-negative bacteria.The anti-infection treatment is mainly cefdiazine and piperacillin/sulbactam, and the combined drug was mainly quinolones.The drug regimen and treatment course are reasonable, there is a high prognosis in the patients.
