Applications of dexmedetomidine by nasal spray during pediatric anesthesia

VernacularTitle: 右美托咪啶喷鼻在儿科麻醉中的应用进展
Author: Qianyun TAO ¹ ; Meiyue TAN ; Lina CHEN ; Youzhuang ZHU ; Jun CHAI
Author Information

1. Department of Anesthesiology, Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China
Publication Type:Review
Keywords: Dexmedetomidine; Administration, intranasal; Anesthesia; Child; Review
From: Journal of Chinese Physician 2019;21(11):1749-1753
CountryChina
Language:Chinese
Abstract: Dexmedetomidine (DEX ) is an α₂ adrenalin-receptor agonist with potent sedation, analgesia, anti-anxiety and anti-sympathetic effect. Moreover, DEX exert no inhibition of respiratory function with high safety and has considerable clinical application prospect. Children often experience emergency agitation (EA) and other uncomfortable symptom which is associated with special physical and mental state. Thus, an ideal pediatric anesthetic premedication is getting a lot of attention. DEX is superior to other premedication in sedation with high safety. Compared with others, DEX by nasal spray is an ideal drug delivery method to reduce the side effects and facilitate the implementation of the drug. The relevant research progress of the effective dose, efficacy and safety will be reviewed.