The failure patterns and related factors of nasopharyngeal carcinoma treated by intensity modulated radiation therapy in Xiangxi area
10.3760/cma.j.issn.1008-1372.2019.11.011
- VernacularTitle: 湘西地区鼻咽癌调强放射治疗失败模式及相关因素分析
- Author:
Jia CHEN
1
;
Zhibi XIANG
2
;
Jingsheng ZHAO
2
;
Ju SU
2
;
Zhi YANG
2
Author Information
1. Medicine School, Jishou University, Jishou 416000, China
2. Department of Oncology, the First Affiliated Hospital of Jishou University, Jishou 416000, China
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Radiotherapy, intensity-modulated;
Prognosis;
Factor analysis, statistical
- From:
Journal of Chinese Physician
2019;21(11):1644-1647,1652
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the failure patterns and related factors of intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) in Xiangxi.
Methods:107 patients with nasopharyngeal carcinoma without distant metastasis were selected from December 2012 to June 2015 in the first affiliated hospital of Jishou University. Locoreginal recurrence-fee survival rate (LRFS), distant metastasis-free survival rate (DMFS) and progression-free survival (FPS) rate were collected. The survival rate was analyzed by Kaplan-Meier method, univariate analysis was analyzed by Logrank method, and multivariate analysis was analyzed by Cox regression.
Results:Tumor progression occurred in 40 cases of 107 patients with nasopharyngeal carcinoma. Among them, 14 cases(13.1%) had local recurrence and 33 cases (30.8%) had distant metastasis. Univariate analysis showed that there was significant difference in LRFS between different ages and T staging (P<0.05). There was significant difference in DMFS and PFS between different gender, ages, diabete history, smoking history, T staging, N stage, clinical stage and treatment mode (P<0.05). Multivariate analysis showed that age and T staging were independent prognostic factors for LRFS. Age, T staging and N staging were independent prognostic factors for DMFS. Age, diabetes, T staging, and N staging were independent prognostic factors for PFS (P<0.05).
Conclusions:Distant metastasis is still the main model of treatment failure of NPC. Age, T staging and N staging before treatment are the significant prognostic factors.
