Effect of the Chaihu-Longgu-Muli decoction on electroencephalogram and expression of brain derived neurotrophie factor in serum of patients with temporal lobe epilepsy
10.3760/cma.j.issn.1008-1372.2019.11.005
- VernacularTitle: 柴胡加龙骨牡蛎汤对颞叶癫痫患者脑电图及血清NGF、BDNF水平的影响
- Author:
Bin ZHOU
1
;
Hongxing HUANG
;
Ping YANG
;
Weiping KUANG
;
Jun LU
;
Yong ZHU
;
Qin WANG
Author Information
1. Department of Neurosurgery, Brain Hospital of Hunan Province, College of Clinical Medicine, Hunan University of Chinese Medicine, Changsha 410007, China
- Publication Type:Journal Article
- Keywords:
Epilepsy, temporal lobe;
CHAIHU LONGGU MULI DECOCTION;
Electroencephalography;
Nerve growth factor;
Brain-derived neurotrophic factor
- From:
Journal of Chinese Physician
2019;21(11):1617-1620
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe influences of Chaihu-Longgu-Muli decoction (CLMD) on electroencephalogram (EEG), serum nerve growth factor (NGF) and brain derived neurotrophie factor (BDNF) level of patients with temporal lobe epilepsy.
Methods:Single blind randomized controlled trial design was used. 138 patients with temporal lobe epilepsy were divided into oxcarbazepine group (including 67 patients), oxcarbazepine+ CLMD group (including 71 patients). After 28 d of treatment, EEG changes, NGF and BDNF changes in serum, and relevant serological indicator inspection of drug reactions in both groups were observed.
Results:The effective rate of EEG in oxcarbazepine+ CLMD group was 81.8%, which was obviously higher than the oxcarbazepine group (50.7%), with significant difference (P<0.01). After treatment, NGF and BDNF of both groups were higher than those before treatment (P<0.05). Moreover, serum NGF and BDNF of oxcarbazepine+ CLMD group were higher than the oxcarbazepine group (P<0.05). There was no statistical significance in serological indicator of drug reactions in both groups (P>0.05).
Conclusions:The curative effects of oxcarbazepine+ CLMD is superior to the individual oxcarbazepine and it can obviously enhance serum NGF and BDNF of patients with temporal lobe epilepsy and reduce the status epilepticus of patients with temporal lobe epilepsy and it has the high safety.
