Dentification and correction of the lead-time bias and length bias in cancer screening studies
10.3760/cma.j.issn.0253-9624.2019.11.022
- VernacularTitle: 肿瘤筛查研究中领先时间偏倚和病程长短偏倚的识别和校正
- Author:
Zhao YANG
1
;
Jiachen ZHOU
2
;
Ru CHEN
3
;
Wenqiang WEI
3
Author Information
1. Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong 999077, China
2. Department of Epidemiology and Biostatistics, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an 710061, China
3. Cancer Registry Office, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
Bias (Epidemiology);
Neoplasms;
Screening
- From:
Chinese Journal of Preventive Medicine
2019;53(11):1183-1187
- CountryChina
- Language:Chinese
-
Abstract:
Lead-time bias and length bias were common systematic errors in observational screening studies, which might be a common cause of overstating or distorting the true screening effects. One of key concerns in observational screening studies was how to estimate the screening effects based on the consideration of these two biases. This paper illustrated how to identify and correct the lead-time bias using the tumor volume doubling time and the non-homogeneous Poisson process, and how to correct the length bias using a weighted method. The application conditions of each method were also discussed to present several useful toolboxes to correct the lead-time bias and length bias appropriately and evaluate the effectiveness of the cancer screening program accurately.
