Progress in genomic DNA methylation of esophageal squamous cell carcinoma
10.3760/cma.j.issn.0253-9624.2019.11.021
- VernacularTitle: 食管鳞癌基因组DNA甲基化的研究进展
- Author:
Jing GUO
1
;
Jiajie HAO
;
Mingrong WANG
Author Information
1. State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Review
- Keywords:
Esophageal neoplasms;
Methylation;
Genome;
Biomarkers
- From:
Chinese Journal of Preventive Medicine
2019;53(11):1176-1182
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal genomic DNA methylation is an important epigenetic change in malignant tumors. Esophageal squamous cell cancer is one of common malignant tumors in our country. In this paper summarized and discussed the progress of genomic DNA methylation in the esophageal squamouscell cancer, including the level of genomic DNA methylation, frequent abnormally methylated genes, methylation markers and potential targets, etc. This paper might provide candidate biomarkers and targets for further studies on the mechanism of the tumorigenesis and development of the esophagealsquamouscell cancer, as well as for the clinical application of esophageal cancer.
