The association between the whole blood riboflavin level and the occurrence, development and prognosis of esophageal squamous cell carcinoma
10.3760/cma.j.issn.0253-9624.2019.11.010
- VernacularTitle: 全血核黄素水平与食管鳞癌发生发展的关联研究
- Author:
Shanshan LI
1
;
Huazhen TAN
2
;
Yiwei XU
2
;
Zhiyong WU
3
;
Jianyi WU
2
;
Xueke ZHAO
4
;
Lidong WANG
4
;
Lin LONG
2
;
Enmin LI
2
;
Liyan XU
2
;
Jianjun ZHANG
5
Author Information
1. Department of Preventive Medicine, Sichuan Nursing Vocational College, Chengdu 610000, China
2. Shantou University Medical College/Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Shantou 515041, China
3. Department of Oncologic Surgery, Shantou Central Hospital/Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou 515041, China
4. Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
5. Department of Public Health, Shantou University Medical College, Shantou 515041, China
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Riboflavin;
Case-control studies
- From:
Chinese Journal of Preventive Medicine
2019;53(11):1124-1129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between the whole blood riboflavin level and the occurrence, development and prognosis of esophageal squamous cell carcinoma (ESCC) in China.
Methods:From March 2014 to September 2018, ESCC patients from three hospitals (the Affiliated Hospital of Medical College of Shantou University, Shantou Central Hospital in Southern Chaoshan area and First Affiliated Hospital of Zhengzhou University in Northern Taihang Mountain) were selected as a case group; non-esophageal patients who had a physical examination were selected as a control group. The case and control group were paired by age (±5 years) and a 1:1 ration. A total of 1 528 subjects were enrolled including 764 patients in the case group and 764 patients in the control group. About 3-5 ml venous blood samples were collected, and the erythrocyte glutathione reductase activity coefficient (GRAC) was measured to assess the whole blood riboflavin level. A multivariate conditional logistic regression model was used to analyze the association between the GRAC and the risk of ESCC. The association between the GRAC and the prognosis of ESCC was analyzed by using Cox proportional risk regression model based on 288 patients with complete survival data. They were divided into two groups, the high GRAC group (GRAC≥7.87) group and the low GRAC group (GRAC<7.87) according to the strongest correlation between the total survival time, survival outcome and GRAC (GRAC=7.87).
Results:Among the 1 528 patients, 958 patients were from Southern Chaoshan area, including 479 patients in the case group with an average age about (59.90±9.34) years and 479 patients in the control group with an average age about (59.55±8.77) years. Other 570 patients were from Northern Taihang Mountain area, including 285 patients in the case group with an average age (58.39±5.19) years and 285 patients in the control group with an average age about (58.74±4.57) years. The multivariate conditional logistic regression showed that the OR (95%CI) of the GRAC and the risk of ESCC was 1.009 (0.998-1.019). The Cox proportional hazard regression model analysis showed that the HR (95%CI) of the high GRAC group was 1.712 (1.034-2.824) compared with the low GRAC group in the 50-70 years group.
Conclusion:The whole blood riboflavin level might not be associated with the occurrence of ESCC. The high whole blood riboflavin level would be more beneficial to the prognosis of ESCC patients aged 50-70 years.
