Status of non-steroidal anti-inflammatory drugs use in areas with a high incidence of upper gastrointestinal cancer in China: a multi-center cross-sectional survey
10.3760/cma.j.issn.0253-9624.2019.11.005
- VernacularTitle: 中国上消化道癌高发区非甾体类抗炎药使用情况研究
- Author:
Shuanghua XIE
1
;
Ru CHEN
1
;
Deli ZHAO
2
;
Yuqin LIU
3
;
Changqing HAO
4
;
Yongzhen ZHANG
5
;
Guohui SONG
6
;
Zhaolai HUA
7
;
Jialin WANG
8
;
Shuzheng LIU
9
;
Liwei ZHANG
10
;
Dantong SHAO
1
;
Yu QIN
1
;
Minjuan LI
1
;
Jiachen ZHOU
1
;
Rongshou ZHENG
1
;
Guiqi WANG
11
;
Wenqiang WEI
1
Author Information
1. Cancer Registry Office, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. Cancer Centre, People′s Hospital of Feicheng, Feicheng 271600, China
3. Cancer EpidemiologyResearch Center, Gansu Provincial Academic Institute for Medical Research, Lanzhou 730030, China
4. Department of Endoscopy, Cancer Institute/Hospital of Linzhou, Linzhou 456500, China
5. Department of Epidemiology, Cancer Hospital of Shanxi Province, Taiyuan 030000, China
6. Department of Epidemiology, Cancer Institute/Hospital of Ci County, Cixian 056500, China
7. People′s Hospital of Yangzhong/Cancer Institute of Yangzhong, Yangzhong 212200, China
8. Department of Science and Education, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China
9. Department of Disease Prevention and Control, Cancer Hospital of Henan Province, Zhengzhou 450000, China
10. Endoscopy Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050019, China
11. Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory agents, non-steroidal;
Cross-sectional study;
Usage
- From:
Chinese Journal of Preventive Medicine
2019;53(11):1098-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the status of non-steroidal anti-inflammatory drugs (NSAIDs) use in areas with a high incidence of upper gastrointestinal cancer in China.
Methods:This study was based on the National Key Research and Development Program of "National Precision Medicine Cohort of Esophageal Cancer" and "Study on Identification and Prevention of High-risk Populations of Gastrointestinal Malignancies (Esophageal cancer, Gastric cancer and Colorectal cancer)" . From January 2017 to August 2018, 212 villages or communities with a high incidence of esophageal cancer or gastric cancer were selected from 12 regions in 6 provinces. A total of 35 910 residents aged between 40 and 69 years old who met the inclusion criteria and signed the informed consent were investigated and enrolled in this study. The use of NSAIDs, demographic characteristics, health-related habits, height, weight, and blood pressure were collected by the questionnaire and physical examination. The status of main NSAIDs (aspirin, acetaminophen and ibuprofen) use with the difference varying in genders, age groups and regions were analyzed by using χ2 test and Cochran-Armitage trend analysis method.
Results:Of 35 910 subjects, the mean age was (54.6±7.1) years old and males accounted for 43.42% (15 591). The overall prevalence of NSAIDs intake was 4.56% (1 638), but it significantly varied in different provinces (P<0.001). The overall prevalence of NSAIDs intake was 4.87% (1 750) in females, which was significantly higher than that in males 4.24% (1 524) (P<0.001). The prevalence of NSAIDs intake increased with age (P for trend <0.001). As the frequency of NSAIDs intake increased, the incidence of gastrointestinal symptoms, gastrointestinal ulcers and black stools increased (P for trend <0.05 for all).
Conclusion:The use of NSAIDs is prevalent in some areas with a high incidence of upper gastrointestinal cancer in China. The increased use of NSAIDs may lead to more adverse effects related to the gastrointestinal tract.