The animal study of echocardiography-guided transthoracic laser ablation of the interventricular septum
10.3760/cma.j.issn.1004-4477.2019.11.015
- VernacularTitle: 超声引导下经胸激光消融室间隔的实验研究
- Author:
Jianli FU
1
,
2
;
Fang LIU
1
,
3
;
Chao SUN
1
,
4
;
Guangbin HE
1
;
Jun ZHANG
1
;
Liwen LIU
1
;
Rui HU
1
;
Hong SHAO
1
;
Wenxia LI
1
Author Information
1. Department of Ultrasonography, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, China
2. Department of Cardiac Surgery, Shaanxi Province People′s Hospital, Xi′an 710068, China
3. Department of Ultrasonography, Xi′an Children′s Hospital, Xi′an 710003, China
4. School of Life Sciences, Northwestern Polytechnical University, Xi′an 710072, China
- Publication Type:Journal Article
- Keywords:
Echocardiography, transthoracic;
Hypertrophic cardiomyopathy;
Septal ablation;
Laser ablation
- From:
Chinese Journal of Ultrasonography
2019;28(11):999-1003
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the safety and long-term efficacy of a new treatment, echocardiography-guided transthoracic laser ablation of the animal interventricular septum (IVS), for obstructive hypertrophic cardiomyopathy (HOCM).
Methods:Ten healthy sheep were randomly divided into two groups: experimental group: sheath puncture with laser ablation (energy: 3 W, 1000 J), sham control group: sheath puncture only without laser ablation. Echocardiography and electrocardiogram (ECG) were recorded before operation, immediately after operation, and 1, 3 and 6-month after the operation. Left ventricular systolic and diastolic function, longitudinal strain, difference of time to peak between the ablation segment and the surrounding segments were analyzed. Blood samples were collected before and one hour after the operation to examine the serological results.
Results:Immediately and 6 months after the operation, all animals survived with normal cardiac function. No severe complications such as cardiac tamponade or bundle branch block occurred. The Troponin I level was significantly elevated immediately after the operation(P<0.05). The thickness of the ablated IVS was significantly reduced 6 months after the operation compared with before the operation[(3.23±1.21)mm vs (8.53±0.44)mm, P<0.05]. M-mode echocardiography showed that the amplitude of movement of the ablated region of the experimental group 6 months after the operation was significantly decreased compared with the control group(P<0.05). Three dimensional strain analysis showed that for the experimental group, the longitudinal strain of the ablation segment was significantly reduced and the difference of time to peak was significantly delayed, compared with the control group(P<0.05).
Conclusions:Echocardiography-guided transthoracic laser ablation of IVS is a safe, effective, and minimally invasive method. It is capable to reduce the volume of IVS without influencing the cardiac function, which makes it a potential alternative for HOCM treatment.
