The relationship of peripheral blood single uncoding RNA-25-3p expression level and the sertraline efficacy in patients with panic disorder
10.3760/cma.j.issn.1674-6554.2019.11.007
- VernacularTitle: 惊恐障碍患者外周血单链非编码RNA-25-3p表达水平与舍曲林疗效的关联性研究
- Author:
Wenjiao MIN
1
;
Chenghui YANG
;
Shuya PAN
;
Yaoyin ZHANG
;
Ying HE
;
Bo ZHOU
Author Information
1. Psychosomatic Department, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu 610072, China
- Publication Type:Clinical Trail
- Keywords:
Panic disorder;
miR-25-3p;
Sertraline;
Effect
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(11):994-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify potential relationship between single uncoding RNA-25-3p (miR-25-3p) expression level and the sertraline efficacy in patients with panic disorder.
Methods:Sixty cases of patients with panic disorder(case group) and sixty healthy-controls(control group) were collected with demographic data and peripheral venous blood before and after treatment.All the patients were evaluated using the 14-item Hamilton Anxiety Rating Scale (HAMA) and Panic Disorder Severity Scale (PDSS) at baseline, and then received sertraline treatment for 6 weeks.After six-week treatment, each patient was evaluated again with HAMA and PDSS.RT-PCR was used to detect the level of miR-25-3p expression.
Results:There was no significant difference in the miR-25-3p levels between control group (1.27±0.32) and case group (1.73±1.09) before treatment(t=1.53, P=0.14), but the levels in case group were much higher than that in control group after the treatment (5.72±4.13 vs 1.73±1.09, t=-2.15, P=0.04). Besides, the changes of the miR-25-3p levels were positively related with both the changes of PDSS3 and PDSS7 items before and after the treatment (r=0.60, P=0.02 for PDSS3 and r=0.61, P=0.02 for PDSS7).
Conclusions:miR-25-3p is associated with the drug efficacy and the outcome of some clinical symptoms of panic disorder.These findings might provide some evidence for the individualized treatment of patients with panic disorder according to regulation of gene expression in the future.
