The predicting value of the 8th edition of American Joint Committee on Cancer staging manual in mucinous breast cancer
10.3760/cma.j.issn.0253-3766.2019.11.010
- VernacularTitle: 第8版美国癌症联合委员会分期对乳腺黏液腺癌预后的预测价值
- Author:
Shuning DING
1
;
Jiayi WU
;
Weiguo CHEN
;
Yafen LI
;
Kunwei SHEN
;
Li ZHU
Author Information
1. Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
- Publication Type:Clinical Trail
- Keywords:
Pure mucinous breast cancer;
American Joint Committee on Cancer staging system;
Prognosis
- From:
Chinese Journal of Oncology
2019;41(11):854-858
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The current study aimed to evaluate the predictive performances of anatomic staging system (AS) and prognostic staging system (PS) proposed in the 8th edition American Joint Committee on Cancer (AJCC) staging manual in patients with pure mucinous breast cancer (PMBC).
Methods:Clinicopathologic features and follow-up information were collected from a total of 3628 patients with PMBC. Breast cancer-specific survival (BCSS) were compared among patients in different stage groups. Likelihood ratio (LR) χ2, Akaike information criterion (AIC) and Harrell′s concordance index (C-index) were used to evaluate the predictive performances of AS and PS in PMBC.
Results:In PMBC, BCSS was associated with tumor size (P=0.002), lymph node status (P=0.002), grade(P=0.003), PR status(P=0.017)and the receipt of radiation. Compared to AS, 1326 patients (37.54%) underwent stage change after applying PS, with 6.50% upstaged and 37.04% downstaged. There were significant differences in BCSS among patients of different stages under the AS and PS (P<0.001). However, PS was not superior to AS in predicting prognosis (AS vs PS, LR χ2: 16.41 vs 17.5; AIC: 357.44 vs 358.35; C-index, 0.72 vs 0.73, P=0.667).
Conclusions:Both of AS and PS proposed in the 8th edition American Joint Committee on Cancer (AJCC) staging manual were predictive factors in patients with PMBC. Compared with AS, the PS did not show superiority in prognosis prediction among patients with PMBC.
