Amplitude of low-frequency fluctuations of resting-state functional MRI in colorectal cancer patients with depression
10.3760/cma.j.issn.0253-3766.2019.11.008
- VernacularTitle: 结直肠癌抑郁患者的静息态脑功能低频振幅研究
- Author:
Lianping ZHAO
1
;
Gang HUANG
1
;
Yaoxing DUAN
2
;
Ying WANG
3
;
Guanmao CHEN
3
;
Wenwen ZHANG
1
Author Information
1. Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China
2. Department of Anorectal Surgery, Gansu Provincial Hospital, Lanzhou 730000, China
3. Institute of Molecular and Functional Imaging, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
- Publication Type:Clinical Trail
- Keywords:
Colorectal neoplasms;
Depression;
Magnetic resonance imaging;
Brain function;
Amplitude of low-frequency fluctuations
- From:
Chinese Journal of Oncology
2019;41(11):844-848
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the alterations of the cerebral resting-state spontaneous neural activity in colorectal cancer patients with depressive symptoms.
Methods:Thirty-three colorectal cancer patients (patient group) with depression and 43 healthy subjects (control group) underwent the resting state functional magnetic resonance imaging (rs-fMRI). The amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) were calculated. Two independent samples t test were used to compare the ALFF and fALFF values between two groups by DPABI software, and then correlation analysis was performed between ALFF and fALFF with statistical significance and Patient Health Questionnaire (PHQ-9) scores and Generalized Anxiety Disorder (GAD-7) scores.
Results:Compared with the control group, the patient group showed significantly lower ALFF and fALFF values in the bilateral precuneus, calcarine gyrus, lingual gyrus, left cuneus, superior, middle, inferior occipital gyrus and right fusiform gyrus (t=-5.730, P<0.05; t=-4.872, P<0.05). There were no significant correlations between the ALFF and fALFF values in these regions and PHQ-9 or GAD-7 scores (P>0.05).
Conclusion:Spontaneous decrease of neural activity in occipital and parietal lobes exists in colorectal cancer patients with depression at resting-sate, which may be a potential neurobiological marker.
