Etiological analysis of hepatopathy of unknown etiology in 470 cases undergoing routine liver biopsy examination
10.3760/cma.j.issn.1007-3418.2019.11.012
- VernacularTitle: 470例行肝穿刺活组织检查的不明原因肝病的病因分析
- Author:
Hongli LIU
1
;
Yongfeng YANG
1
,
2
;
Qingfang XIONG
2
;
Yandan ZHONG
2
;
Duxian LIU
3
;
Ping HUANG
2
;
Xiaoning FENG
2
Author Information
1. School of Medicine, Southeast University, Nanjing 210009, China
2. Department of Liver Diseases, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing 210003, China
3. Department of Pathology, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing 210003, China
- Publication Type:Journal Article
- Keywords:
Biopsy, needle;
Pathology;
Unknow etiology hepatopathy
- From:
Chinese Journal of Hepatology
2019;27(11):885-889
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the etiology of hepatopathy of unknown etiology in patients undergoing liver biopsy.
Methods:Demographic data and pathological examination reports of patients with hepatopathy of unknown etiology who underwent liver biopsy examination at outpatient and inpatient of the Second Hospital of Nanjing between January 2017 and June 2018 were retrospectively collected. All liver histopathological sections combined with clinical and pathological features based on liver biopsy examinations were diagnosed by a reputed clinician and a pathologist.
Results:A total of 470 cases with hepatopathy of unknown etiology who underwent liver biopsy were enrolled. Of these, 425 cases (90.4%) had a definite diagnosed disease after comprehensive analysis of pathological and clinical data. The diagnosis of hepatopathy of unknown etiology included 11 diseases: 90 cases with autoimmune hepatitis had autoimmune liver disease (19.1%), 38 cases had primary biliary cholangitis (8.1%), 43 cases with overlap syndrome of autoimmune hepatitis had primary biliary cholangitis (9.1%), 118 cases had drug-induced liver injury (25.1%), 75 cases had nonalcoholic fatty liver disease (NAFLD) (16.0%), 12 cases had alcoholic liver disease (2.6 cases) %), 15 cases (3.2%) had vascular liver disease, 7 cases (1.5%) had hereditary metabolic liver disease, 5 cases (1.1%) had other systemic diseases, 16 cases (3.4%) had more than two kinds of liver diseases, and 6 cases (1.3%) had others rare liver diseases.
Conclusion:Over 90% cause of the hepatopathy of unknown etiology in the long run can be determined, and the main causes are autoimmune liver disease, drug-induced liver injury, and nonalcoholic fatty liver disease, which needs multidisciplinary cooperation to diagnose, and clinicians need to master the basic and clinical knowledge of liver diseases as well as liver pathology, hepatobiliary imaging, and genetics.
