Application of indocyanine green fluorescence imaging in open hepatectomy
10.3760/cma.j.issn.1007-8118.2019.11.003
- VernacularTitle: 吲哚菁绿荧光成像在开腹肝癌切除术中的应用分析
- Author:
Pan HE
1
;
Song SU
1
;
Cheng FANG
1
;
Kai HE
1
;
Chongwei CHI
2
;
Xianming XIA
1
;
Jie TIAN
2
;
Bo LI
1
Author Information
1. Department of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
2. Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
- Publication Type:Journal Article
- Keywords:
Hepatectomy;
Margins of excision;
Indocyanine green;
Fluorescence imaging
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(11):809-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical application of indocyanine green fluorescence imaging in open hepatectomy.
Methods:A total of forty-five patients who underwent liver resection in Department of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical University from July 2017 to December 2018 were included in this prospective study. There were 26 males and 19 females, aged between 29 to 74 (51±10) years. Indocyanine green was injected intravenously 72~96 hours prior to surgery in all these patients. An intraoperative fluorescence imaging system was used to locate and remove the tumor, the liver parenchymal transection planes and surgical margins were detected by fluorescence again after tumor resection. The fluorescence profiles of the tumor specimens in relation to the tumor differentiation were analyzed.
Results:Indocyanine green fluorescence imaging was performed in 45 patients. A total of 66 lesions were detected by preoperative CT (or MRI), abdominal ultrasound and intraoperative fluorescence imaging. After excision of the primary liver cancer, the surgical margins of the remnant liver stumps and fluorescence in the excised liver specimens were studied. Thirteen small lesions were found in 10 patients, most of which were located at the surgical margin, and the smallest tumors detected were less than 5 mm in diameter. Five venous cancer emboli were found in 5 patients, 3 of which were not detected by preoperative imaging examinations. The fluorescence profile images of the excised hepatocellular carcinoma specimens showed homogeneous fluorescence in most highly differentiated hepatocellular carcinoma, and partial fluorescence or ring fluorescence in moderately differentiated hepatocellular carcinoma.
Conclusion:Indocyanine green fluorescence imaging technology can identify liver surface lesions, as well as detect small residual lesions at the cutting edge and venous thrombus, which improves the efficiency of hepatocellular carcinoma resection.
