Impact of Pringle’s maneuver on postoperative serum inflammatory mediator levels and prognosis of HBV-related HCC patients
10.3760/cma.j.issn.1007-8118.2019.11.001
- VernacularTitle: 肝门阻断对乙型肝炎病毒相关性肝细胞癌患者术后血清炎症介质水平及预后的影响
- Author:
Huayong CAI
1
;
Fanyu MENG
2
;
Shichun LU
1
Author Information
1. Medical School of Nankai University, Tianjin 300071, China
2. Department of Hepatobiliary Surgery, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Hepatitis B virus;
Prognosis;
Pringle maneuver;
Inflammatory mediator
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(11):801-805
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the impact of Pringle’s maneuver on postoperative serum inflammatory mediator levels and prognosis in hepatitis B virus-related hepatocellular carcinoma (HBV related HCC) patients.
Methods:A retrospective study was conducted on 157 HBV related HCC patients who underwent treatment at the Chinese PLA General Hospital from January 2016 to December 2017. There were 128 males and 29 females. The mean age was (54.5±12.1) years. These patients were divided into 106 patients who underwent Pringle’s maneuver (the Pringle’s maneuver group). The remaining patients were in the Occlusion-free group. All patients were detected inflammatory mediator levels including the various interleukins (IL) and were regularly followed up. The recurrence-free survival was evaluated by the Kaplan-Meier method, and compared with the log-rank test. The relationship between the Pringle’s maneuver and risks of postoperative tumor recurrence of these patient were estimated by the univariate and multivariate Cox regression models.
Results:On postoperation day 1 and day 3, the serum IL-1 and IL-6 levels of the Pringle’s maneuver group were significantly higher than the Occlusion-free group [5.0(5.0, 12.0)ng/L vs. 5.0(5.0, 5.0)ng/L], [122.0(74.5, 173.8)ng/L vs. 80.0(40.0, 120.0)ng/L]; [5.0(5.0, 10.0)ng/L vs. 5.0(5.0, 5.0)ng/L], [78.3(42.8, 138.5)ng/L vs. 48.1(30.1, 75.0)ng/L]. On day 5, the serum IL-1 and IL-8 levels were also significantly higher than the Occlusion-free group [5.0(5.0, 5.3)ng/L vs. 5.0(5.0, 5.0)ng/L], [100.6 (44.2, 186.5)g/L vs. 68.0(36.3, 112.0)ng/L] (all P<0.05). There were 42 and 27 patients who did not develop recurrence in the Pringle’s Maneuver group and the Occlusion-free group, respectively. The recurrence-free survival rates of the Pringle maneuver group and the Occlusion-free group were 40.0% and 52.9%, respectively. There were no significant differences between the two groups (P>0.05). The multivariate Cox regression model suggested that there was no significant correlation between Pringle’s maneuver and recurrence free survival of these patients with HBV related HCC.
Conclusions:Pringle’s maneuver could significantly elevate the postoperative serum IL-1, IL-6, IL-8 levels, but it was not related with an increased risk of postoperative tumor recurrence.
