The research progress of keratin′s roles in the pathology of middle ear cholesteatoma

VernacularTitle: 角蛋白在中耳胆脂瘤病理过程中的作用及研究进展
Author: Yisi FENG ¹ ; Yu SI ¹ ; Zhigang ZHANG ¹
Author Information

1. Department of Otorhinolaryngology Head and Neck Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
Publication Type:Review
Keywords: Keratins; Cholesteatoma, middle ear; Cell proliferation; Bone resorption
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2019;54(11):870-874
CountryChina
Language:Chinese
Abstract: Keratin (K) is the main component of the epithelial cell mesenchymal cytoskeleton, which protects the integrity of epithelial cells and maintains the function of normal epithelial cells. The expression of keratin affects epidermal proliferation and differentiation, and so as to be used as a marker for proliferation, differentiation and migration of keratinocytes. Middle ear cholesteatoma is one of the common ear diseases. In the middle ear cholesteatoma, keratinocytes over-proliferate and keratin debris accumulates. In this paper, we reviewed the recent studies on middle ear cholesteatoma and explained the possible mechanisms of keratin in the pathogenesis of middle ear cholesteatoma from the aspects of "proliferation" and " bone resorption ". At the same time, the existing problems as well as the prospect of the future research were discussed.