Neurofibrillary tangle-predominant dementia

VernacularTitle: 神经原纤维缠结优势型痴呆
Author: Wenzheng HU ¹ ; Shuai LIU ^{1
,

2} ; Jinghuan GAN ¹ ; Zhanglong LI ³ ; Zhihong SHI ² ; Yanfeng LI ⁴ ; Yong JI ^{2
,

3}
Author Information

1. Graduate School of Tianiin Medical University, Tianjin 300070, China
2. Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China
3. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
4. Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, China
Publication Type:Review
Keywords: Neurofibrillary tangle; Dementia; Nerve degeneration
From: Chinese Journal of Geriatrics 2019;38(11):1312-1316
CountryChina
Language:Chinese
Abstract: Neurofibrillary tangle-predominant dementia(NFTPD)is one type of late-onset dementia, with memory disorders as the main clinical manifestation.The pathological feature is the presence of a large number of neurofibrillary tangle(NFT)in the hippocampus with no or little amyloid deposition in the brain.In recent years, primary age-related tauopathy(PART)has been proposed as a new pathological term, which means that NFT appears in the medial temporal lobe with aging, but no amyloid deposits, and NFTPD is one type of dementia associated with the progression of PART.